Document Detail


Gene expression in the human brain: the current state of the study of specificity and spatiotemporal dynamics.
MedLine Citation:
PMID:  23145569     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gene expression is one of the main molecular processes regulating the differentiation, development, and functioning of cells and tissues. In this review a handful of relevant terms and concepts are introduced and the most common techniques used in studies of gene expression/expression profiling (also referred to as studies of the transcriptome or transcriptomics) are described. The main foci of this review are the advancements in studies of the transcriptome in the human brain, the transcriptome's variability across different brain structures, and the systematic changes that occur through different developmental stages across the life span in general and childhood in particular. Finally, the question of how the accumulating data on the spatial and temporal dynamics of the transcriptome may shed light on the molecular mechanisms of the typical and atypical development of the central nervous system is addressed.
Authors:
Oksana Yu Naumova; Maria Lee; Sergei Yu Rychkov; Natalia V Vlasova; Elena L Grigorenko
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-11-12
Journal Detail:
Title:  Child development     Volume:  84     ISSN:  1467-8624     ISO Abbreviation:  Child Dev     Publication Date:    2013 Jan-Feb
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-07-03     Revised Date:  2014-05-01    
Medline Journal Info:
Nlm Unique ID:  0372725     Medline TA:  Child Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  76-88     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Child Development © 2012 Society for Research in Child Development, Inc.
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MeSH Terms
Descriptor/Qualifier:
Aging / genetics
Autopsy
Brain / embryology,  growth & development,  physiology*
Gene Expression / genetics*
Gene Expression Profiling / methods
Gene Expression Regulation, Developmental / genetics*
Humans
Oligonucleotide Array Sequence Analysis / methods
Sequence Analysis / methods
Transcriptome / genetics
Grant Support
ID/Acronym/Agency:
R01 DC007665/DC/NIDCD NIH HHS; R01 DC007665/DC/NIDCD NIH HHS
Comments/Corrections

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