Document Detail

Gene Expression Differences in Healthy Brachial and Femoral Arteries of Rapacz Familial Hypercholesterolemic Swine.
MedLine Citation:
PMID:  21505098     Owner:  NLM     Status:  Publisher    
Objective: The mechanisms underlying the unequal distribution of atherosclerotic disease in the peripheral arteries are currently unclear. Gene expression differences in healthy arteries may influence the heterogeneous distribution of atherosclerosis. Therefore, this investigation compares gene expression in healthy atheroprotected brachial and atherosusceptible femoral arteries of young and disease free Rapacz Familial Hypercholesterolemic (FHC) swine. We hypothesized that transcripts related to atherosusceptibility would be differentially expressed between these arteries prior to the onset of disease. Methods and Results: Femoral and brachial arteries were harvested from four 13 day old Rapacz FHC swine. No atherosclerotic disease was detected using Sudan IV, VVG, and H/E staining. Gene expression was quantified using Affymetrix GeneChip Porcine Genome Arrays. An average of 15552 probe sets had detectable transcripts, while 430 probe sets showed a significant differential expression between arteries (FDR<0.05). The human orthologs of 63 probe sets with differential expression and a 1.5fold or greater transcript abundance between arteries are associated with Wnt/β-catenin, lysophospholipid, and Ca-signaling, as well as apoptosis. Conclusion: This is the first investigation reporting that differences in relative abundance of gene expression exist between brachial and femoral arteries in young Rapacz FHC swine prior to the development of atherosclerotic lesions.
Martin Bahls; Christopher A Bidwell; Juan Hu; Christian G Krueger; Jess D Reed; Armando Tellez; Greg L Kaluza; Juan F Granada; William G Van Alstine; Sean C Newcomer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-19
Journal Detail:
Title:  Physiological genomics     Volume:  -     ISSN:  1531-2267     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815683     Medline TA:  Physiol Genomics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Purdue University.
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