| Gender-specific role of mitochondria in the vulnerability of 6-hydroxydopamine-treated mesencephalic neurons. | |
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MedLine Citation:
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PMID: 20416276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many neurodegenerative diseases, such as Morbus Parkinson, exhibit a gender-dependency showing a higher incidence in men than women. Most of the neurodegenerative disorders involve either causally or consequently a dysfunction of mitochondria. Therefore, neuronal mitochondria may demonstrate a gender-specificity with respect to structural and functional characteristics of these organelles during toxic and degenerative processes. The application of 6-OHDA (6-hydroxydopamine) in vitro and in vivo represents a well-accepted experimental model of Parkinson's disease causing Parkinsonian symptoms. Besides the known effects of 6-OHDA on mitochondria and neuronal survivability, we aimed to demonstrate that the mitochondrial neurotoxin affects the morphology and survival of primary dopaminergic and non-dopaminergic neurons in the mesencephalon in a gender-specific manner by influencing the transcription of mitochondrial genes, ATP and reactive oxygen species production. Our data suggest that cell death in response to 6-OHDA is primarily caused due to increased oxidative stress which is more pronounced in male than in female mesencephalic neurons. |
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Authors:
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Magdalena Misiak; Cordian Beyer; Susanne Arnold |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-20 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1797 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2010 Jun-Jul |
Date Detail:
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Created Date: 2010-06-21 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1178-88 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Institute for Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Apoptosis / drug effects Base Sequence Cell Death / drug effects Cells, Cultured DNA Primers / genetics Dopamine / metabolism Electron Transport Chain Complex Proteins / genetics Estradiol / pharmacology Female Gene Expression / drug effects Male Mesencephalon / drug effects*, metabolism, pathology Mice Mice, Inbred BALB C Mitochondria / drug effects*, metabolism, pathology Models, Neurological Necrosis Neurons / drug effects*, metabolism, pathology Oxidopamine / toxicity* Parkinsonian Disorders / chemically induced, genetics, metabolism, pathology Reactive Oxygen Species / metabolism Sex Characteristics |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Electron Transport Chain Complex Proteins; 0/Reactive Oxygen Species; 1199-18-4/Oxidopamine; 50-28-2/Estradiol; 56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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