Document Detail

Gender-specific role of mitochondria in the vulnerability of 6-hydroxydopamine-treated mesencephalic neurons.
MedLine Citation:
PMID:  20416276     Owner:  NLM     Status:  MEDLINE    
Many neurodegenerative diseases, such as Morbus Parkinson, exhibit a gender-dependency showing a higher incidence in men than women. Most of the neurodegenerative disorders involve either causally or consequently a dysfunction of mitochondria. Therefore, neuronal mitochondria may demonstrate a gender-specificity with respect to structural and functional characteristics of these organelles during toxic and degenerative processes. The application of 6-OHDA (6-hydroxydopamine) in vitro and in vivo represents a well-accepted experimental model of Parkinson's disease causing Parkinsonian symptoms. Besides the known effects of 6-OHDA on mitochondria and neuronal survivability, we aimed to demonstrate that the mitochondrial neurotoxin affects the morphology and survival of primary dopaminergic and non-dopaminergic neurons in the mesencephalon in a gender-specific manner by influencing the transcription of mitochondrial genes, ATP and reactive oxygen species production. Our data suggest that cell death in response to 6-OHDA is primarily caused due to increased oxidative stress which is more pronounced in male than in female mesencephalic neurons.
Magdalena Misiak; Cordian Beyer; Susanne Arnold
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-20
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1797     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:    2010 Jun-Jul
Date Detail:
Created Date:  2010-06-21     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1178-88     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Institute for Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany.
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MeSH Terms
Adenosine Triphosphate / metabolism
Apoptosis / drug effects
Base Sequence
Cell Death / drug effects
Cells, Cultured
DNA Primers / genetics
Dopamine / metabolism
Electron Transport Chain Complex Proteins / genetics
Estradiol / pharmacology
Gene Expression / drug effects
Mesencephalon / drug effects*,  metabolism,  pathology
Mice, Inbred BALB C
Mitochondria / drug effects*,  metabolism,  pathology
Models, Neurological
Neurons / drug effects*,  metabolism,  pathology
Oxidopamine / toxicity*
Parkinsonian Disorders / chemically induced,  genetics,  metabolism,  pathology
Reactive Oxygen Species / metabolism
Sex Characteristics
Reg. No./Substance:
0/DNA Primers; 0/Electron Transport Chain Complex Proteins; 0/Reactive Oxygen Species; 1199-18-4/Oxidopamine; 50-28-2/Estradiol; 56-65-5/Adenosine Triphosphate

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