Document Detail


Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke.
MedLine Citation:
PMID:  22202639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epigenetic alterations may mechanistically explain the developmental origins of adult disease, namely the hypothesis that many complex adult chronic diseases originate as a result of conditions encountered in utero. If true, epigenetically regulated imprinted genes, critical to normal growth and development, may partially mediate these outcomes. We determined the influence of in utero exposure to cigarette smoking on methylation at two differentially methylated regions (DMRs) regulating Insulin-like Growth Factor 2 (IGF2) and H19, and how this might relate to birth weight of infants born to 418 pregnant women. Smoking status was ascertained through self-report and medical records. Bisulfite pyrosequencing was used to measure methylation in umbilical cord blood DNAs. Least squares DNA methylation means at each DMR and birth weight were compared between infants of smokers and non-smokers, using generalized linear models. While there were no significant differences at the H19 DMR, infants born to smokers had higher methylation at the IGF2 DMR than those born to never smokers or those who quit during pregnancy (49.5%, SD=8.0 versus 46.6%, SD=5.6 and 45.8%, SD=6.3, respectively; p=0.0002). The smoking-related increase in methylation was most pronounced in male offspring (p for sex interaction=0.03), for whom approximately 20% of smoking-related low birth weight was mediated by DNA methylation at the IGF2 DMR. Our findings suggest that IGF2 DMR plasticity is an important mechanism by which in utero adjustments to environmental toxicants are conferred. Larger studies to replicate these findings are required.
Authors:
Susan K Murphy; Abayomi Adigun; Zhiqing Huang; Francine Overcash; Frances Wang; Randy L Jirtle; Joellen M Schildkraut; Amy P Murtha; Edwin S Iversen; Cathrine Hoyo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-12-20
Journal Detail:
Title:  Gene     Volume:  494     ISSN:  1879-0038     ISO Abbreviation:  Gene     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-24     Completed Date:  2012-03-30     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7706761     Medline TA:  Gene     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  36-43     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University Medical Center, Durham, NC 27708, USA. susan.murphy@duke.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Weight
DNA Methylation*
Female
Fetal Blood / chemistry
Genomic Imprinting*
Humans
Insulin-Like Growth Factor II / genetics*
Male
Maternal-Fetal Exchange*
Pregnancy
RNA, Long Untranslated
RNA, Untranslated*
Sex Characteristics*
Smoking / genetics*
Grant Support
ID/Acronym/Agency:
R01 DK085173/DK/NIDDK NIH HHS; R01 ES016772/ES/NIEHS NIH HHS; R01DK085173/DK/NIDDK NIH HHS; R01ES016772/ES/NIEHS NIH HHS; R21 ES014947/ES/NIEHS NIH HHS; R21ES014947/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/H19 long non-coding RNA; 0/RNA, Long Untranslated; 0/RNA, Untranslated; 67763-97-7/Insulin-Like Growth Factor II
Comments/Corrections

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