| Gender-specific effects of calcitonin gene-related peptide and substance P on coronary blood flow in an experimental model. | |
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MedLine Citation:
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PMID: 19017671 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Calcitonin gene-related peptide (CGRP) and substance P (SP) play counter-regulatory roles in coronary flow. This study is to assess whether effects of CGRP and SP are gender-specific. METHODS: Langendorff-perfused hearts were used to compare coronary flow rates among 119 wild-type, alpha-CGRP and SP receptor knockout mice under various perfusion pressures (20, 30, 40, 50 mmHg). RESULTS: For mouse heart coronary flow rate, deletion of alpha-CGRP gene resulted in significant reduction for both genders at all pressures; female CGRP knockout showed 15.3% reduction (P < .01); male CGRP knockout showed 13.8% reduction (P < .01); no significant difference between male and female CGRP knockout; female SP receptor knockout showed 13.9% increase (P < .01); female SP receptor knockout had a greater percentage decrease than male (P < .01). CONCLUSIONS: CGRP plays similar roles as a vasodilator in males and females. SP seems to act as a vasoconstrictor in females. |
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Authors:
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Ma Hongbao; Yang Yan; Cherng Shen |
Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article Date: 2008-11-17 |
Journal Detail:
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Title: Angiology Volume: 60 ISSN: 1940-1574 ISO Abbreviation: Angiology Publication Date: 2009 Oct-Nov |
Date Detail:
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Created Date: 2009-10-23 Completed Date: 2009-11-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: United States |
Other Details:
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Languages: eng Pagination: 569-75 Citation Subset: IM |
Affiliation:
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Bioengineering Department, Zhengzhou University, Zhengzhou, Henan, China. hongbao@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity Calcitonin Gene-Related Peptide / metabolism* Coronary Circulation* Coronary Vessels / metabolism* Female Male Mice Mice, Inbred C57BL Mice, Knockout Models, Animal Perfusion Receptors, Calcitonin Gene-Related Peptide / deficiency, genetics Receptors, Neurokinin-1 / deficiency, genetics Sex Factors Substance P / metabolism* Vasoconstriction* Vasodilation* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Calcitonin Gene-Related Peptide; 0/Receptors, Neurokinin-1; 33507-63-0/Substance P; 83652-28-2/Calcitonin Gene-Related Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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