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Gender-specific early-postnatal catch-up growth after intrauterine growth retardation by food restriction in swine with obesity/leptin resistance.
MedLine Citation:
PMID:  22692087     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The effects of undernutrition during pregnancy on prenatal and postnatal development of the offspring were evaluated in sows with obesity/leptin resistance. Females were fed, from Day 35 of pregnancy onwards, a diet fulfilling either 100% (group control, n = 10) or 50% of the nutritional requirements (group underfed, n = 10). In the control group, maternal body-weight increased during pregnancy (P<0.05) whilst it decreased or remained steady in the underfed group. At Days 75 and 100 of gestation, plasma triglycerides were lower but urea levels were higher in restricted than in control sows (P<0.05 for both). Assessment of the offspring indicated that the trunk diameter was always smaller in the restricted group (P<0.01 at Day 50, P<0.005 at Days 75 and 100, P<0.0001 at birth) whilst head measurements were similar through pregnancy, although smaller in the restricted than in the control group at birth (P<0.05). Newborns from restricted sows were also lighter than offspring from control females (P<0.01) and had higher incidence of growth retardation (P<0.01). Afterwards, during lactation, early postnatal growth in restricted piglets was modulated by gender. At weaning, males from restricted sows were still lighter than their control counterparts (P<0.05), whilst females from control and underfed sows were similar. Thus, the current study indicates a gender-related differential effect in the growth patterns of the piglets, with females from restricted sows evidencing catch-up growth to neutralize prenatal retardation and reaching similar development than control counterparts.
Authors:
Antonio Gonzalez-Bulnes; Cristina Ovilo; Clemente J Lopez-Bote; Susana Astiz; Miriam Ayuso; Mariluz Perez-Solana; Raul Sanchez-Sanchez; Laura Torres-Rovira
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-12
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  -     ISSN:  1741-7899     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
A Gonzalez-Bulnes, Reproduccion Animal, INIA, Madrid, 28040, Spain.
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