Document Detail

Gender-specific differences in left ventricular remodelling in obesity: insights from cardiovascular magnetic resonance imaging.
MedLine Citation:
PMID:  23053174     Owner:  NLM     Status:  MEDLINE    
AIMS: As obesity-related cardiovascular mortality, although elevated when compared with normal weight, is lower in females than in males at every body mass index (BMI) level, we aimed to investigate gender-specific differences in left ventricular (LV) hypertrophy in obesity, which themselves have been shown to have varying prognostic value.
METHOD AND RESULTS: In total, 741 subjects (female, n = 399) without identifiable cardiovascular risk factors (BMI 15.7-59.2 kg/m(2)) underwent cardiovascular magnetic resonance (1.5 T) to determine LV mass, end-diastolic volume (EDV, mL), and LV mass/volume ratio (LVM/VR). Across both sexes, there was a strong positive correlation between BMI and LV mass (male r = 0.44, female r = 0.57, both P < 0.001), with males showing a greater LV hypertrophic response (male +2.3 vs. female +1.6 g per BMI point increase, P = 0.001). Concentric hypertrophy was present in both sexes and LVM/VR positively correlated to BMI (male r = 0.45, female r = 0.29, both P < 0.001) on linear regression analysis. However, the degree of concentric hypertrophy was greater in males (male +0.13 vs. female +0.06 LVM/VR increase per BMI point increase, P = 0.001). On the other hand, females showed a greater LV cavity dilatory response (female +1.1 vs. male +0.3 mL per BMI point increase, P < 0.001). Indeed, in contrast to females, where BMI and LV-EDV were positively correlated (r = 0.38, P < 0.001), BMI did not correlate with EDV in men (r = 0.03, P = 0.62).
CONCLUSION: In the absence of traditional cardiovascular risk factors, obese men show predominantly concentric hypertrophy, whereas obese women exhibit both eccentric and concentric hypertrophy. As concentric hypertrophy is more strongly related to cardiovascular mortality than eccentric hypertrophy, our observations may explain the observed gender difference in obesity-related mortality.
Oliver J Rider; Adam Lewandowski; Richard Nethononda; Steffen E Petersen; Jane M Francis; Alex Pitcher; Cameron J Holloway; Sairia Dass; Rajarshi Banerjee; James P Byrne; Paul Leeson; Stefan Neubauer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-10
Journal Detail:
Title:  European heart journal     Volume:  34     ISSN:  1522-9645     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-22     Completed Date:  2013-07-03     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  292-9     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Body Mass Index
Hypertrophy, Left Ventricular / pathology,  physiopathology
Magnetic Resonance Angiography
Middle Aged
Obesity / pathology,  physiopathology*
Sex Characteristics
Stroke Volume / physiology
Ventricular Function, Left / physiology
Ventricular Remodeling / physiology*
Young Adult
Grant Support
FS/08/077/26366//British Heart Foundation; FS/11/65/28865//British Heart Foundation; //Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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