| Gender risk of nonfatal stroke in type 2 diabetic patients differs depending on the type of treatment. | |
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MedLine Citation:
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PMID: 19105694 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The gender differences in stroke risk among diabetic patients with different treatments have not been studied previously. We aim to determine if there is a gender difference in nonfatal stroke risk in diabetic patients receiving different types of glucose-lowering treatments. METHODS: In December 2005, data of type 2 diabetic patients were extracted from a nationwide population-based diabetes registry covering 11 Ukrainian regions. Male/female odds ratios (OR) for nonfatal stroke were calculated in three treatment groups: diet only 7,273/15,901, oral glucose-lowering drugs 15,109/33,913, and insulin 5,529/12,462 male/female. Male/female ORs of stroke were estimated using a logistic regression model. RESULTS: The age-adjusted ORs of stroke were higher among diabetic men compared with diabetic women with oral glucose-lowering drug treatment (OR 1.37, 95% CI 1.22-1.54) and diet treatment only (OR 1.53, 95% CI 1.35-1.73). No differences were found among patients who used insulin (OR 0.97, 95% CI 0.84-1.11). Further adjustment for duration of type 2 diabetes, body mass index (BMI), systolic blood pressure, total cholesterol, and smoking affected the results only slightly. CONCLUSIONS: The gender risks of nonfatal stroke in patients with type 2 diabetes appear to differ considerably depending on treatment types. |
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Authors:
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Mykola Khalangot; Gang Hu; Mykola Tronko; Victor Kravchenko; Vitaliy Guryanov |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of women's health (2002) Volume: 18 ISSN: 1931-843X ISO Abbreviation: J Womens Health (Larchmt) Publication Date: 2009 Jan-Feb |
Date Detail:
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Created Date: 2009-01-09 Completed Date: 2009-04-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101159262 Medline TA: J Womens Health (Larchmt) Country: United States |
Other Details:
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Languages: eng Pagination: 97-103 Citation Subset: IM |
Affiliation:
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Institute of Endocrinology and Metabolism, Kiev, Ukraine. nikhalangot@ukr.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Glucose / drug effects Body Mass Index Cross-Sectional Studies Diabetes Mellitus, Type 2 / complications, diet therapy*, drug therapy* Diabetic Diet / utilization* Female Humans Hypoglycemic Agents / classification, therapeutic use* Insulin / therapeutic use Logistic Models Male Men's Health Middle Aged Odds Ratio Prevalence Registries Risk Factors Sex Factors Stroke / epidemiology*, etiology Time Factors Ukraine / epidemiology Women's Health |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hypoglycemic Agents; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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