Document Detail

Gender-related disparities in non-small cell lung cancer.
MedLine Citation:
PMID:  20826048     Owner:  NLM     Status:  MEDLINE    
Epidemiological studies clearly outline some disparities in cancer onset, progression as well as prognosis and therapeutic response between sexes. In particular, in lung cancer, the leading cause of cancer death, at least in Western countries, a gender disparity appears now to emerge, especially for non-small cell lung cancer (NSCLC). Such a disparity is apparently due to a variety of mechanisms, ranging from genetic and epigenetic differences to gender-specific lifestyle as well as to behavioral causes and, clearly, to sex hormones activity. Here we briefly recapitulate gender differences in terms of risk factors, histopathological features and pathogenetic mechanisms in NSCLC, and hypothesize that a gender-oriented pharmacology could beneficially impact on innovative therapeutic strategies.
Marco G Paggi; Rosa Vona; Claudia Abbruzzese; Walter Malorni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-09-09
Journal Detail:
Title:  Cancer letters     Volume:  298     ISSN:  1872-7980     ISO Abbreviation:  Cancer Lett.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Department of Development of Therapeutic Programs, National Cancer Institute "Regina Elena", Via Elio Chianesi 53, 00144 Rome, Italy.
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MeSH Terms
Carcinoma, Non-Small-Cell Lung / epidemiology*,  genetics,  pathology
Disease Progression
Lung Neoplasms / epidemiology*,  genetics,  pathology
Sex Factors

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