| Gender-related differences in outcome after ST-segment elevation myocardial infarction treated by primary angioplasty and glycoprotein IIb-IIIa inhibitors: insights from the EGYPT cooperation. | |
| | |
MedLine Citation:
|
PMID: 20213259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Several studies have found that among patients with ST-elevation myocardial infarction (STEMI) treated by thrombolysis, female sex is associated with a worse outcome. The aim of this study was to investigate sex-related differences in clinical and angiographic findings in patients with STEMI treated with primary angioplasty and Gp IIb-IIIa inhibitors. Our population is represented by 1662 patients undergoing primary angioplasty included in the EGYPT database. Myocardial perfusion was evaluated by myocardial blush grade and ST-segment resolution. Follow-up data were collected between 30 days and 1 year after primary angioplasty. Among 1662 patients, 379 were women (22.8%). Female sex was associated with more advanced age, higher prevalence of diabetes, hypertension, more advanced Killip class, longer ischemia time, less often smokers, with higher prevalence of preprocedural recenalization. No difference was observed in terms of postprocedural TIMI flow, myocardial perfusion and distal embolization. Similar findings were observed in terms of enzymatic infarct size and preprocedural ejection fraction. Female gender was associated with higher mortality (6.4% vs. 3.6%, HR = 1.83 [1.12-3.0], P = 0.015). However, the difference disappeared after correction for baseline confounding factors (HR = 1.01 [0.56-1.83], P = 0.98). This study shows that in patients with STEMI treated by primary angioplasty, female gender is associated with higher mortality rate in comparison with men, and this is mainly due to their higher clinical and angiographic risk profiles. In fact, female sex did not emerge as an independent predictor of mortality. |
| | |
Authors:
|
Giuseppe De Luca; C Michael Gibson; Mariann Gyöngyösi; Uwe Zeymer; Dariusz Dudek; Hans-Richard Arntz; Francesco Bellandi; Mauro Maioli; Marko Noc; Simona Zorman; H Mesquita Gabriel; Ayse Emre; Donald Cutlip; Tomasz Rakowski; Kurt Huber; Arnoud W J van't Hof |
Related Documents
:
|
11553909 - Application of excimer laser angioplasty in acute myocardial infarction. 2528079 - Transluminal angioplasty of intracerebral vessels for cerebral arterial spasm: reversal... 2294679 - Usefulness of coronary angioplasty in asymptomatic patients. 10149209 - Percutaneous coronary angioscopy: methods, findings, and therapeutic implications. 8888669 - Explaining discrepant mortality results between primary percutaneous transluminal coron... 8914779 - Abrupt (< 1 day), acute (< 1 week), and early (< 1 month) vessel closure at the angiopl... 19851079 - Soluble e-selectin is an inverse and independent predictor of left ventricular wall thi... 1383999 - Transcoronary chemical ablation of arrhythmias. 10935769 - Emergency coronary artery bypass surgery after failed percutaneous transluminal coronar... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of thrombosis and thrombolysis Volume: 30 ISSN: 1573-742X ISO Abbreviation: J. Thromb. Thrombolysis Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-24 Completed Date: 2011-02-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9502018 Medline TA: J Thromb Thrombolysis Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 342-6 Citation Subset: IM |
Affiliation:
|
Division of Cardiology, Maggiore della Carità Hospital, Eastern Piedmont University, Novara, Italy. giuseppe.deluca@maggioreosp.novara.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Angioplasty* / adverse effects, mortality Female Humans Male Middle Aged Mortality Myocardial Infarction / complications, epidemiology*, etiology, mortality, therapy* Platelet Aggregation Inhibitors / therapeutic use Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors* Risk Factors Sex Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Platelet Aggregation Inhibitors; 0/Platelet Glycoprotein GPIIb-IIIa Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Biochemical markers for the diagnosis of venous thromboembolism: the past, present and future.
Next Document: Factors associated with recruiting an HIV seropositive risk network member among injection drug user...