Document Detail

Gender-related differences in the clinical course of Crohn's disease.
MedLine Citation:
PMID:  11374696     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to analyze the clinical and epidemiological differences between women and men affected by Crohn's disease. METHODS: The clinical course of 275 female Crohn's disease patients was compared with that of 266 male patients. RESULTS: Mean age at onset of symptoms and at diagnosis was 25.7 yr versus 27.7 yr and 28.8 yr versus 30.7 yr in women and men, respectively. Mean lag-time between onset of symptoms and establishment of the diagnosis were similar in both groups, without differences in presenting symptoms and initial localization of lesions. In women, however, some extraintestinal manifestations of Crohn's disease were found to occur more often. The percentage of patients who underwent an abdominal operation was quite similar in both groups (81% vs 77%). Mean lag-time between onset of symptoms and first bowel resection was not different. However, the lag-time between bowel resection and recurrence of disease was significantly shorter in women than in men (respectively, 4.8 yr vs 6.5 yr, p = 0.04), particularly regarding primary ileocecal resections. Overall, ileocecal resections were significantly more frequently performed in female than male patients (44% and 32%, respectively, p = 0.004). Female patients were also found to have significantly more often relatives in the first or second degree affected by Crohn's disease than male patients (15% vs 8.3%, p = 0.02). CONCLUSIONS: Extraintestinal manifestations occur more often in female Crohn's disease patients than in male patients. Furthermore, an ileocecal resection, which is accompanied by an earlier recurrence, is more often performed in female than in male patients. Female patients have more often relatives with the same disease.
M J Wagtmans; H W Verspaget; C B Lamers; R A van Hogezand
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  96     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-25     Completed Date:  2001-06-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1541-6     Citation Subset:  IM    
Department of Gastroenterology and Hepatology, Leiden University Medical Center, The Netherlands.
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MeSH Terms
Cecum / surgery
Crohn Disease / complications,  genetics,  physiopathology*,  surgery
Digestive System Surgical Procedures / statistics & numerical data
Ileum / surgery
Sex Characteristics*
Sex Distribution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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