Document Detail

Gender-related differences in cardiomyopathy.
MedLine Citation:
PMID:  2492448     Owner:  NLM     Status:  MEDLINE    
As with other cardiovascular diseases, there are sufficient data to suggest significant gender-related differences in the prevalence and presentation of congestive heart failure and myocardial diseases. From animal studies, it is apparent that there are sex-related differences in intrinsic ventricular function and in the cardiovascular response to various stimuli, which are at least partly modulated through direct effects of sex hormones on the heart. Although similar data are not available in humans, it seems likely that similar gender-related differences in cardiac function exist and may in part account for the observed differences in myocardial diseases in men and women. Additionally, genetic factors may contribute to these differences, as X-linked disorders may present differently in males and females. An awareness of the impact of sex-related factors is clearly important in the evaluation of any patient presenting with heart failure or cardiomyopathy and may alter both diagnostic and therapeutic considerations, as well as broaden our basic knowledge and understanding of the pathogenetic mechanisms involved in myocardial dysfunction.
B A Berko
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Cardiovascular clinics     Volume:  19     ISSN:  0069-0384     ISO Abbreviation:  Cardiovasc Clin     Publication Date:  1989  
Date Detail:
Created Date:  1989-03-23     Completed Date:  1989-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213744     Medline TA:  Cardiovasc Clin     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  285-300     Citation Subset:  IM    
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MeSH Terms
Cardiomyopathies* / epidemiology,  etiology
Cardiomyopathy, Dilated / genetics
Cardiovascular System / metabolism
Diabetes Complications
Fabry Disease / genetics
Gonadal Steroid Hormones / physiology
Linkage (Genetics)
Mucopolysaccharidoses / genetics
Muscular Dystrophies / genetics
Sex Characteristics*
X Chromosome / ultrastructure
Reg. No./Substance:
0/Gonadal Steroid Hormones

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