| Gender-limited association of cytotoxic T-lymphocyte antigen-4 (CTLA-4) polymorphism with cord blood IgE levels. | |
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MedLine Citation:
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PMID: 15610363 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Allergic mechanism has long been attributed to IgE-mediated reaction. The relationship between gene polymorphism and cord blood IgE (CB IgE) is unclear. We investigated whether elevation of CB IgE levels was associated with polymorphisms of cytotoxic T-lymphocyte antigen 4 (CTLA-4) at (-318) CT and (+49) AG positions in a gender-limited fashion. CB IgE levels were determined by Pharmacia CAP system and the CTLA-4 polymorphisms at (-318) and (+49) were determined by restriction fragment length polymorphism (RFLP). A total of 644 consecutive umbilical cord bloods were collected for this study. 32.9% of newborn infants had detectable IgE levels (> or =0.35 kU/l). 25.6% of the male newborns had elevated CB IgE levels (> or =0.5 kU/l) similar to those of the female newborns (22.7%). The CTLA-4 polymorphism at (+49) but not (-318) was significantly associated with elevated CB IgE levels (p = 0.004). The association of CTLA-4 (+49) A allele with elevated CB IgE levels was found only in females. Both male and female infants with different CTLA-4 (-318) genotypes had no difference in the rates of elevated CB IgE levels. A linkage disequilibrium between CTLA-4 (+49) G and (-318) C allele was found in this Chinese population. Subjects with the (+49, GG and -318, CC) genotype had a significantly lower rate of elevated CB IgE levels. Association of the CTLA-4 (+49) polymorphism with elevated CB IgE levels was found only in female infants. Newborn infants with the (+49, GG and -318, CC) genotype tended to have a low rate of elevated CB IgE. |
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Authors:
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Jen-Chieh Chang; Chieh-An Liu; Hau Chuang; Chia-Yu Ou; Te-Yao Hsu; Eng-Yen Huang; Kuender D Yang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Volume: 15 ISSN: 0905-6157 ISO Abbreviation: Pediatr Allergy Immunol Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-21 Completed Date: 2005-05-26 Revised Date: 2008-05-28 |
Medline Journal Info:
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Nlm Unique ID: 9106718 Medline TA: Pediatr Allergy Immunol Country: England |
Other Details:
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Languages: eng Pagination: 506-12 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Chang Gung Memorial Hospital, Kaohsiung, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD Antigens, Differentiation / blood*, genetics* Chi-Square Distribution Female Fetal Blood / immunology* Humans Immunoglobulin E / blood*, genetics* Immunosuppressive Agents / blood* Infant, Newborn Male Polymorphism, Genetic / genetics, physiology* Polymorphism, Restriction Fragment Length Sex Factors Taiwan |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, Differentiation; 0/Immunosuppressive Agents; 0/cytotoxic T-lymphocyte antigen 4; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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