Document Detail


Gender-limited association of cytotoxic T-lymphocyte antigen-4 (CTLA-4) polymorphism with cord blood IgE levels.
MedLine Citation:
PMID:  15610363     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Allergic mechanism has long been attributed to IgE-mediated reaction. The relationship between gene polymorphism and cord blood IgE (CB IgE) is unclear. We investigated whether elevation of CB IgE levels was associated with polymorphisms of cytotoxic T-lymphocyte antigen 4 (CTLA-4) at (-318) CT and (+49) AG positions in a gender-limited fashion. CB IgE levels were determined by Pharmacia CAP system and the CTLA-4 polymorphisms at (-318) and (+49) were determined by restriction fragment length polymorphism (RFLP). A total of 644 consecutive umbilical cord bloods were collected for this study. 32.9% of newborn infants had detectable IgE levels (> or =0.35 kU/l). 25.6% of the male newborns had elevated CB IgE levels (> or =0.5 kU/l) similar to those of the female newborns (22.7%). The CTLA-4 polymorphism at (+49) but not (-318) was significantly associated with elevated CB IgE levels (p = 0.004). The association of CTLA-4 (+49) A allele with elevated CB IgE levels was found only in females. Both male and female infants with different CTLA-4 (-318) genotypes had no difference in the rates of elevated CB IgE levels. A linkage disequilibrium between CTLA-4 (+49) G and (-318) C allele was found in this Chinese population. Subjects with the (+49, GG and -318, CC) genotype had a significantly lower rate of elevated CB IgE levels. Association of the CTLA-4 (+49) polymorphism with elevated CB IgE levels was found only in female infants. Newborn infants with the (+49, GG and -318, CC) genotype tended to have a low rate of elevated CB IgE.
Authors:
Jen-Chieh Chang; Chieh-An Liu; Hau Chuang; Chia-Yu Ou; Te-Yao Hsu; Eng-Yen Huang; Kuender D Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  15     ISSN:  0905-6157     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-21     Completed Date:  2005-05-26     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  506-12     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD
Antigens, Differentiation / blood*,  genetics*
Chi-Square Distribution
Female
Fetal Blood / immunology*
Humans
Immunoglobulin E / blood*,  genetics*
Immunosuppressive Agents / blood*
Infant, Newborn
Male
Polymorphism, Genetic / genetics,  physiology*
Polymorphism, Restriction Fragment Length
Sex Factors
Taiwan
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation; 0/Immunosuppressive Agents; 0/cytotoxic T-lymphocyte antigen 4; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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