Document Detail


Gender impact on first trimester markers in Down syndrome screening.
MedLine Citation:
PMID:  12478634     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of fetal gender on the level in the first trimester of the serological markers alpha-fetoprotein (AFP), pregnancy-associated plasma protein-A (PAPP-A) and free beta human chorionic gonadotropin (betahCG) and on nuchal translucency is described for 2637 singleton pregnancies with normal outcome. Mean log MoM values for pregnancies with female and male fetuses were calculated using regression of log marker values on gestational age expressed as crown rump length and on maternal weight. A pronounced gender impact was found for free betahCG, being 16% higher for female than for male fetuses.
Authors:
Severin Olesen Larsen; Karen R Wøjdemann; Anne-Cathrine Shalmi; Karin Sundberg; Michael Christiansen; Ann Tabor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  22     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-12     Completed Date:  2003-06-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  1207-8     Citation Subset:  IM    
Copyright Information:
Copyright 2002 John Wiley & Sons, Ltd.
Affiliation:
Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark. sol@ssi.dk
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood*
Chorionic Gonadotropin, beta Subunit, Human / blood
Denmark / epidemiology
Down Syndrome / diagnosis*,  epidemiology
Female
Humans
Male
Mass Screening
Neck / embryology,  ultrasonography
Pregnancy / blood*
Pregnancy Trimester, First
Pregnancy-Associated Plasma Protein-A / analysis
Prenatal Diagnosis
Sex Characteristics*
alpha-Fetoproteins / analysis
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/alpha-Fetoproteins; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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