Document Detail


Gender and gonadal status modulation of dorsal raphe nucleus serotonergic neurons. Part I: effects of gender and pregnancy.
MedLine Citation:
PMID:  12504918     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gender differences in susceptibility to affective disorders are well documented. The ovarian steroids, estrogen (E) and progesterone (P), may modulate the function of the serotonergic (5-HT) system, implicated in the etiology and treatment of affective disorders. We tested the hypothesis that ovarian steroid modulation of 5-HT function could result in a modification of the 5-HT neuronal firing activity. Extracellular unitary recordings of dorsal raphe nucleus 5-HT neurons were obtained in male rats and in female rats during natural E and P fluctuations. The average firing activity of 5-HT neurons was significantly higher in males (41%) than in freely cycling (CF) and in ovariectomized (OVX) females. During pregnancy, it increased gradually and by up to 136% on gestational day 17, then declined before parturition. In the postpartum period (PP), the firing rate decreased markedly compared to P17 but remained 63% higher than in CF. During pregnancy, the firing rate variations were closely correlated with P plasmatic levels. Finally no modification of the basal firing activity of locus coeruleus noradrenergic neurons was found in any group tested. Our results thus reveal a gender and pregnancy-dependent modulation of 5-HT firing rate that would impact 5-HT-mediated neurotransmission.
Authors:
R Klink; M Robichaud; G Debonnel
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropharmacology     Volume:  43     ISSN:  0028-3908     ISO Abbreviation:  Neuropharmacology     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-30     Completed Date:  2003-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0236217     Medline TA:  Neuropharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  1119-28     Citation Subset:  IM    
Affiliation:
McGill University, Department of Psychiatry, 1033 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology
Animals
Estrogens / blood
Female
Male
Neurons / physiology*
Ovariectomy
Pregnancy / blood,  physiology*
Progesterone / blood
Raphe Nuclei / physiology*
Rats
Rats, Sprague-Dawley
Serotonin / physiology*
Sex Characteristics*
Chemical
Reg. No./Substance:
0/Estrogens; 50-67-9/Serotonin; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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