Document Detail

Gender and exercise influence on tissue antioxidant vitamin status in rats.
MedLine Citation:
PMID:  10737224     Owner:  NLM     Status:  MEDLINE    
Although gender differences in antioxidant status based largely on differing estrogen levels have been postulated, it is not known if other gender based differences in tissue antioxidants exist. This experiment examined whether gender based differences in tissue vitamin C and vitamin E concentration exist, and investigated the possibility of gender based differences in indices of tissue oxidative stress following an acute exercise bout. It was determined that female rats had significantly higher levels of vitamin E in liver and heart tissues than males and that males had significantly more vitamin C in the plantaris muscle than females. However, female rats also had less liver glutathione than males. Acute exercise resulted in significant and equal tissue oxidative stress in both genders as indicated by tissue glutathione status. With some exceptions, tissue vitamin C and vitamin E concentrations were generally unaffected by acute exercise in either gender. Hence, while some gender differences in tissue antioxidant status in rats are evident, these differences do not affect tissue indices of oxidative stress following acute exercise.
P M Tiidus; E Bombardier; N Hidiroglou; R Madere
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nutritional science and vitaminology     Volume:  45     ISSN:  0301-4800     ISO Abbreviation:  J. Nutr. Sci. Vitaminol.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-06-06     Completed Date:  2000-06-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0402640     Medline TA:  J Nutr Sci Vitaminol (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  701-10     Citation Subset:  IM; S    
Department of Kinesiology and Physical Education, Wilfrid Laurier University, Waterloo ON, Canada.
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MeSH Terms
Antioxidants / metabolism*
Ascorbic Acid / metabolism*
Glutathione / metabolism
Glutathione Disulfide / metabolism
Liver / metabolism
Muscles / metabolism
Myocardium / metabolism
Oxidative Stress
Physical Conditioning, Animal / physiology*
Sex Characteristics*
Vitamin E / metabolism*
Reg. No./Substance:
0/Antioxidants; 1406-18-4/Vitamin E; 27025-41-8/Glutathione Disulfide; 50-81-7/Ascorbic Acid; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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