| Gender does not influence event-free survival in patients with ischaemic heart disease undergoing non-emergency coronary angiography. A single centre analysis. | |
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MedLine Citation:
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PMID: 17577844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although gender-related differences in cardiovascular risk in patients with acute coronary syndromes have been investigated several times in Poland, there are few data on the effects of gender on management of patients with stable ischaemic heart disease (IHD). In addition, available data on the prognosis in this condition in men and women are also scarce. AIM: To assess gender-related differences in treatment and event-free survival in patients with IHD undergoing non-emergency coronary angiography. METHODS: 960 consecutive patients with IHD undergoing coronary angiography were included. Study end points were ascertained over 4.5-year follow-up in 925 patients, of whom 187 were women and 738 were men. The primary end-point consisted of cardiovascular death, myocardial infarction, stroke, cardiac arrest, PCI, CABG or heart transplantation. RESULTS: Female gender was independently related to higher prescription rate of beta-blockers [odds ratio 1.89 (95% CI 1.08-3.29)], ACE inhibitors [1.47 (1.01-2.16)] and calcium antagonists [1.65 (1.08-2.53)] at the time of coronary angiography. On the other hand, female gender was not independently related to the probability of PCI [1.01 (0.69-1.49)] or CABG [0.91 (0.57-1.48)]. We did not find any gender-related difference in the risk of the primary end point [hazard ratio 0.94 (95% CI 0.67-1.34)] or the three predefined secondary end points. CONCLUSIONS: Female gender was independently related to a higher prescription rate of beta-blockers, ACE inhibitors and calcium antagonists. No gender-related revascularisation was found in respect of myocardial revascularisation. Gender was not an independent factor affecting event-free survival in patients with IHD undergoing non-emergency coronary angiography. |
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Authors:
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Piotr Jankowski; Kalina Kawecka-Jaszcz; Danuta Czarnecka; Leszek Bryniarski; Małgorzata Brzozowska-Kiszka; Beata Kieć-Wilk; Grzegorz Dymek; Ewa Kopacz; Tadeusz Królikowski; Dariusz Dudek |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Kardiologia polska Volume: 65 ISSN: 0022-9032 ISO Abbreviation: Kardiol Pol Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-06-19 Completed Date: 2007-09-04 Revised Date: 2007-12-19 |
Medline Journal Info:
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Nlm Unique ID: 0376352 Medline TA: Kardiol Pol Country: Poland |
Other Details:
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Languages: eng Pagination: 475-84; discussion 485 Citation Subset: IM |
Affiliation:
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1st Department of Cardiology, Collegium Medicum Jagiellonian University, Cracow, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use Aged Angioplasty, Transluminal, Percutaneous Coronary Angiotensin-Converting Enzyme Inhibitors / therapeutic use Calcium Channel Blockers / therapeutic use Coronary Angiography* Coronary Artery Bypass Female Follow-Up Studies Humans Male Middle Aged Myocardial Ischemia / drug therapy, mortality, radiography*, therapy Poland Risk Factors Sex Distribution Sex Factors Survival Analysis Survival Rate Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Calcium Channel Blockers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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