| Gender differences in short-term cardiovascular outcomes after percutaneous coronary interventions. | |
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MedLine Citation:
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PMID: 16784919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent studies have been inconsistent in demonstrating a decrease in the gender gap in short-term post-percutaneous coronary intervention (PCI) outcomes. We sought to determine gender differences in outcomes in younger and older patients who underwent PCI during the current stent era. We studied 4,768 elective PCI procedures performed at Emory University Hospital from 2001 to 2004. The baseline characteristics, periprocedural complications, angiographic success, procedural success, and major in-hospital complications (death, myocardial infarction, and emergency coronary artery bypass graft surgery) after PCI were compared between men and women. Women were more likely to be nonwhite and older, with a greater prevalence of hypertension and diabetes mellitus (all p <0.001) compared with men. After adjusting for baseline characteristics and coronary artery size, the incidence of coronary vascular injury complications was higher in women than in men, particularly in patients <or=55 years (odds ratio [OR] 2.74, 95% confidence interval [CI] 1.49 to 5.04). The difference was less when comparing women and men >55 years (OR 1.32, 95% CI 0.87 to 1.99, p = 0.047 for gender-age interaction). The adjusted odds of bleeding complications were also higher in women than in men (<or=55 years OR 5.39, 95% CI 2.26 to 12.8, >55 years OR 2.55, 95% CI 1.68 to 3.87, p = 0.121 for gender-age interaction). No significant gender differences were present in a combined end point of death, myocardial infarction, and emergency coronary artery bypass graft surgery. In conclusion, among patients who have undergone PCI, women, particularly younger women, are more likely than men to experience coronary vascular injury and bleeding complications unaccounted for by coronary artery size and other patient characteristics. No differences were found in major in-hospital complications by gender. |
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Authors:
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Edgar Argulian; Amar D Patel; Jerome L Abramson; Aniket Kulkarni; Kimberly Champney; Spencer Palmer; William Weintraub; Nanette K Wenger; Viola Vaccarino |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-05-04 |
Journal Detail:
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Title: The American journal of cardiology Volume: 98 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-20 Completed Date: 2006-08-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 48-53 Citation Subset: AIM; IM |
Affiliation:
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Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary* / adverse effects, statistics & numerical data Coronary Artery Disease / mortality, therapy* Female Hospital Mortality* Hospitalization Humans Male Middle Aged Multivariate Analysis Sex Factors Survival Rate Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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K24HL077506/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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