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Gender differences in risk factors for intracranial cerebral atherosclerosis among asymptomatic subjects.
MedLine Citation:
PMID:  21497768     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Gender is known to be one of the factors linked to differences in cardiovascular morbidity and mortality. However, little information is available regarding gender differences in the risk factors for intracranial cerebral atherosclerosis (ICAS).
OBJECTIVE: This study investigated the risk factors for ICAS separately by gender in an asymptomatic population.
METHODS: We collected data from a consecutive series of 935 subjects who had no history of stroke and who had undergone transcranial Doppler ultrasonography (TCD). For each subject, their medical history was documented and tests for biochemical markers were performed. Multiple logistic regression analyses were separately conducted to assess the risk factors associated with ICAS by gender.
RESULTS: The risk factors for asymptomatic ICAS were determined for every 10-year increase in age (odds ratio [OR] = 1.74, 95% confidence interval [CI] = 1.23-2.46), diabetes mellitus (DM) (OR = 3.45, 95% CI = 1.49-7.95), smoking (OR = 2.09, 95% CI = 1.01-4.32), and hypercholesterolemia (OR = 3.31, 95% CI = 1.15-9.50) for male subjects; risk factors female subjects included hypertension (OR = 2.10, 95% CI = 1.40-3.15) and DM (OR = 2.45, 95% CI = 1.11-5.44). An additional stratified analysis indicated that there was no significant risk factor for male subjects aged <50 years, whereas hypertension (OR = 2.90, 95% CI = 1.57-5.37) was the significant risk factor for female subjects aged <50 years. For male subjects aged ≥50 years, DM (OR = 6.00, 95% CI = 1.87-19.20), hypercholesterolemia (OR = 4.72, 95% CI = 1.05-21.19), and every 10-year increase in age (OR = 4.33, 95% CI = 2.02-9.28) were significant risk factors for asymptomatic ICAS, whereas DM (OR = 2.93, 95% CI = 1.14-7.48) was significant for female subjects aged ≥50 years.
CONCLUSIONS: The findings suggest that the risk factors for asymptomatic ICAS differ between sexes, indicating a possible role of sex hormones in the development of ICAS.
Young-Suk Kim; Jin-Woo Hong; Woo-Sang Jung; Seong-Uk Park; Jung-Mi Park; Sung-Il Cho; Young-Min Bu; Sang-Kwan Moon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gender medicine     Volume:  8     ISSN:  1878-7398     ISO Abbreviation:  Gend Med     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-04-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101225178     Medline TA:  Gend Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14-22     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier HS Journals, Inc. All rights reserved.
Department of Cardiovascular and Neurologic Disease, College of Oriental Medicine, Kyung Hee University, Seoul, Korea.
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