Document Detail

Gender differences in pulmonary arterial reactivity to dilatory agonists in pulmonary hypertension.
MedLine Citation:
PMID:  14513574     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine whether impaired reactivity to dilatory agonists could contribute to pulmonary hypertension, and whether there are gender differences in pulmonary vasodilator reactivity. METHODS: Pulmonary arterial rings from monocrotaline (MCT)-induced pulmonary hypertensive and control rats were isolated. At the peaks of submaximal contractions to norepinephrine (NE) or endothelin (ET-1), rings were exposed to 5 x 10(-6) M acetylcholine (ACh) or 9 x 10(-9) M adrenomedullin (ADM) or 1.3 x 10(-8) M calcitonin gene-related peptide (CGRP). RESULTS: Relaxation to ACh, ADM, and CGRP was endothelium-dependent. Hypertensive pulmonary arterial rings relaxed less to ACh and CGRP than controls in both genders. Female pulmonary hypertensive muscle was more rather than less reactive to ADM compared with controls. ADM-induced relaxation of NE contractions was 2.4 times greater in female compared with male control rings and 5.5 times greater in female compared with male hypertensive preparations. Gender differences in relaxation responses were similar for CGRP. MCT-treated female arterial rings relaxed more than did MCT-treated male arterial muscle in response to ACh. No difference in ACh relaxation was found between genders for controls. CONCLUSIONS: Pulmonary arterial relaxation to endothelium-dependent vasodilators is impaired in MCT-induced pulmonary hypertension with the exception of ADM in females. Vasodilators may be more effective in reducing pulmonary hypertension in females than in males.
C Subah Packer; Tomalyn C Johnson; Palaniswamy Vijay; Thomas G Sharp; Deepika Jha; Shannon M Tighe; Helen V Chukwu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia     Volume:  6     ISSN:  1523-7036     ISO Abbreviation:  J Gend Specif Med     Publication Date:  2003  
Date Detail:
Created Date:  2003-09-29     Completed Date:  2003-11-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100887298     Medline TA:  J Gend Specif Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  30-8     Citation Subset:  IM    
Indiana University School of Medicine, Department of Cellular & Integrative Physiology, 635 Barnhill Drive, Indianapolis, IN 46202, USA.
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MeSH Terms
Acetylcholine / pharmacology
Calcitonin Gene-Related Peptide / pharmacology
Endothelins / diagnostic use
Hypertension, Pulmonary / chemically induced*
Monocrotaline / diagnostic use
Norepinephrine / diagnostic use
Peptides / pharmacology
Pulmonary Artery / drug effects*
Rats, Sprague-Dawley
Vasodilation / drug effects
Vasodilator Agents / pharmacology*
Reg. No./Substance:
0/Endothelins; 0/Peptides; 0/Vasodilator Agents; 148498-78-6/Adrenomedullin; 315-22-0/Monocrotaline; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine; 83652-28-2/Calcitonin Gene-Related Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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