| Gender differences in patients with acute ST-elevation myocardial infarction complicated by cardiogenic shock. | |
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MedLine Citation:
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PMID: 19856196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: The aim of our analysis is to assess gender differences in baseline characteristics, acute therapies, and clinical outcome in patients with acute ST-elevation myocardial infarction (STEMI) complicated by cardiogenic shock. METHODS: The Maximal Individual Therapy of Acute Myocardial Infarction PLUS registry (MITRA PLUS) is a German prospective, multicenter, observational data pool of current treatment of STEMI. RESULTS: STEMI was more often (P < 0.0001) complicated by cardiogenic shock in female patients (12.9%) when compared to male patients (9.3%). This was still true after adjusting for confounding variables (OR 1.19, 95% CI 1.09-1.30). Women with STEMI admitted in a cardiogenic shock were older (P < 0.0001) and had more often concomitant diseases (P < 0.0001). There was no differences in rates of reperfusion therapy (OR 0.92, 95% CI 0.77-1.09). Hospital mortality was 67.7% in female patients, when compared to 57.2% in male patients (P < 0.0001). After adjusting for confounding variables in the multivariate analysis hospital mortality did not differ between men and women (OR 1.16, 95% CI 0.98-1.38). Early reperfusion therapy was associated with a significant reduction of hospital mortality in female patients with STEMI complicated by cardiogenic shock (OR 0.68, 95% CI 0.52-0.90) with primary PCI being more effective than thrombolytic therapy (OR 0.46, 95% CI 0.31-0.68). CONCLUSION: In women, STEMI was more often complicated by cardiogenic shock when compared to men. However, the use of early reperfusion therapy did not differ between the sexes. Primary PCI was associated with the best outcome in female patients with STEMI complicated by cardiogenic shock and is therefore the therapy of choice. |
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Authors:
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Oliver Koeth; Ralf Zahn; Tobias Heer; Timm Bauer; Claus Juenger; B?rbel Klein; Anselm Kai Gitt; Jochen Senges; Uwe Zeymer |
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Publication Detail:
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Type: Journal Article Date: 2009-10-25 |
Journal Detail:
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Title: Clinical research in cardiology : official journal of the German Cardiac Society Volume: 98 ISSN: 1861-0692 ISO Abbreviation: Clin Res Cardiol Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264123 Medline TA: Clin Res Cardiol Country: Germany |
Other Details:
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Languages: eng Pagination: 781-6 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Herzzentrum Ludwigshafen, Ludwigshafen, Germany. oliver-koeth@web.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Angioplasty, Transluminal, Percutaneous Coronary / methods* Female Fibrinolytic Agents / therapeutic use Germany Hospital Mortality Humans Male Myocardial Infarction / complications, therapy* Myocardial Reperfusion / methods* Registries Sex Factors Shock, Cardiogenic / complications, therapy* Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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