Document Detail


Gender differences in patients with coronary artery disease in Japan: the Japanese Coronary Artery Disease Study (the JCAD study).
MedLine Citation:
PMID:  19276612     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Gender differences among patients with coronary artery disease vary from study to study. In one of the largest studies, the Japanese Coronary Artery Disease (JCAD) Study, gender differences in patients were investigated. METHODS AND RESULTS: Consecutive patients diagnosed with stenosis 75% or more in at least one branch of the coronary arteries were enrolled in the study. The endpoint is a composite of all-cause death and cardiovascular events. Data were collected over the internet. Out of 15,628 patients screened, 13,812 of them met the inclusion criteria and were followed up for a mean period of 2.7 years. The event rate was 62.8 per 1,000 patients-year, all-cause death 17.3 and total cardiac events 47.4. The incident rate of unstable angina was higher in females (27.1) than males (21.8) (P=0.0363). The incidence of all-cause death was lower in females than males (16.9 and 17.8, respectively; P=0.0148). Other than gender, hypertension and number of vessel disease contribute to the event of unstable angina, and age, family history, obesity, impaired fasting glycemia, hyperlipidemia, congestive heart failure and number of vessel disease contribute to the all-cause death. CONCLUSIONS: Gender is an independent contributing factor of unstable angina and of all-cause death.
Authors:
Hirofumi Kambara; Tsutomu Yamazaki; Doubun Hayashi; Takahide Kohro; Yoshihiro Okada; Ryozo Nagai;
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-11
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  73     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-24     Completed Date:  2009-08-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  912-7     Citation Subset:  IM    
Affiliation:
Cardiovascular Center, Shizuoka General Hospital, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Angina, Unstable / ethnology,  etiology
Asian Continental Ancestry Group / statistics & numerical data*
Cardiovascular Diseases / ethnology*,  etiology,  mortality
Coronary Angiography
Coronary Stenosis / complications,  ethnology*,  mortality,  radiography
Databases as Topic
Female
Follow-Up Studies
Humans
Incidence
Japan / epidemiology
Male
Middle Aged
Proportional Hazards Models
Risk Assessment
Risk Factors
Severity of Illness Index
Sex Factors
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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