Document Detail

Gender differences in the long QT syndrome: effects of beta-adrenoceptor blockade.
MedLine Citation:
PMID:  11861047     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Gender differences have been reported in patients with the congenital long QT syndrome (LQTS). We analyzed whether electrocardiographic differences existed in females, males, girls and boys in response to beta-adrenoceptor blockade. METHODS: 12-lead ECGs before and during beta-adrenoceptor blockade were collected in 87 genotyped LQTS patients (48 women, 14 men, 12 girls and 13 boys). Up to three QTc intervals were determined in each lead of the ECG. V4 was used for QT/QTc analysis. Difference between longest and shortest QT interval was taken as a measure for dispersion of QT intervals. RESULTS: (1) Adult males had the greatest shortening of the QTc interval upon treatment with beta-adrenoceptor blockade. During treatment, adult males with LQTS(1) (mutation in the KCNQ1 gene, affecting I(Ks) current) were found to have shorter QTc intervals than adult females; this difference did not exist in LQTS(2) patients (mutation in the HERG gene, affecting I(Kr) current). (2) Female LQTS(2) patients had a 50% larger dispersion than female LQTS(1) patients both before and during treatment. (3) Adult male LQTS(1) patients constitute the only patient group with a marked decrease in QTc intervals and dispersion associated with a 100% efficacy of treatment in response to beta-adrenoceptor blockade. CONCLUSIONS: These findings indicate that, in addition to underlying differences in repolarization between men and women, cardiac electrophysiological responses to beta-adrenoceptor blockade can be modulated by gender-related factors.
Chantal E Conrath; Arthur A M Wilde; Rosalie J E Jongbloed; Mariëlle Alders; Irene M van Langen; J Peter van Tintelen; Pieter A Doevendans; Tobias Opthof
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular research     Volume:  53     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-03-07     Completed Date:  2002-04-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  770-6     Citation Subset:  IM    
Department of Cardiology, University Medical Center, Utrecht, The Netherlands
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Analysis of Variance
KCNQ Potassium Channels
KCNQ1 Potassium Channel
Long QT Syndrome / drug therapy,  genetics*,  physiopathology*
Mutation, Missense
Potassium Channels / genetics
Potassium Channels, Voltage-Gated*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/KCNQ Potassium Channels; 0/KCNQ1 Potassium Channel; 0/KCNQ1 protein, human; 0/Potassium Channels; 0/Potassium Channels, Voltage-Gated

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