| Gender differences in drug toxicity. | |
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MedLine Citation:
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PMID: 20117848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinical data suggest that gender dimorphic profiles are emerging in terms of both drug efficacy and adverse drug reactions (ADRs). With an increasing emphasis on individualised therapies and the need to prevent drug attrition there is a compelling need to understand the molecular basis for gender dimorphic profiles in ADRs and the consequences. Classes of agents exhibiting gender-based variation in pharmaceutical efficacy and toxicity include anaesthetics, HIV-1 therapies and antiarrhythmic drugs. Body weight differences are often cited as a reason for differences in drug pharmacokinetics and subsequent toxicity. However, some studies accounted for these factors and still found significance suggesting that dosage versus body weight does not explain the outcome. Here, we present an overview of current understanding of gender-specific drug toxicity and present rational molecular explanations for these adverse events. There is mounting evidence in support of hormonal effects underpinning the majority of the ADR differences observed between the sexes. |
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Authors:
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Tamara J Nicolson; Howard R Mellor; Ruth R A Roberts |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-02-01 |
Journal Detail:
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Title: Trends in pharmacological sciences Volume: 31 ISSN: 1873-3735 ISO Abbreviation: Trends Pharmacol. Sci. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-08 Completed Date: 2010-06-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906158 Medline TA: Trends Pharmacol Sci Country: England |
Other Details:
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Languages: eng Pagination: 108-14 Citation Subset: IM |
Copyright Information:
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2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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General Toxicology Sciences, Safety Assessment UK, AstraZeneca R&D, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK. Tamara.Nicolson@astrazeneca.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carrier Proteins
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metabolism Drug Toxicity / etiology* Female Hormones / metabolism Humans Male Pharmaceutical Preparations / adverse effects*, metabolism Sex Characteristics* |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Hormones; 0/Pharmaceutical Preparations |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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