Document Detail


Gender differences in clinical presentation and prognosis of uveal melanoma.
MedLine Citation:
PMID:  23197684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: We examined the clinical differences in manifestation and prognosis of uveal melanoma (UM) between men and women.
METHODS: We evaluated 723 UM patients (325 males) who were treated between 1988 and 2010 at a national referral center. Men and women were compared regarding differences in annual distribution, age at diagnosis, size and intraocular location of the tumor, symptoms leading to diagnosis, recurrence, development of metastases, and mortality. Statistical analysis included ANOVA, Pearson correlations, and competing risks for melanoma-related mortality.
RESULTS: Significant gender differences were not found for annual distribution, diagnosis age, tumor size, or recurrence rate. Tumors were located more frequently posterior to the equator in men than in women. However, men were less likely than women to complain of symptoms before the diagnosis (77.10% vs. 84.65%). Men suffered more metastases. In the subgroup of patients who had metastases, the time until development of metastases was shorter in men (metastases 1 and 5 years after diagnosis of UM: 26% vs. 12.96% and 84% vs. 50%, respectively). The cumulative incidence for melanoma-related mortality was higher for men, with an almost two-fold excess of male melanoma-related mortality in the first 10 years after the diagnosis of UM.
CONCLUSIONS: Men have earlier and more frequent metastases in the first decade after the diagnosis of UM, a fact that may have significant implications in planning clinical trials to test adjuvant therapies to prevent metastasis.
Authors:
Ofira Zloto; Jacob Pe'er; Shahar Frenkel
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2013-01-23
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  54     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-24     Completed Date:  2013-03-19     Revised Date:  2013-08-08    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  652-6     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Israel / epidemiology
Male
Melanoma / epidemiology*
Middle Aged
Morbidity / trends
Prognosis
Retrospective Studies
Risk Assessment / methods*
Risk Factors
Sex Distribution
Sex Factors
Survival Rate / trends
Uveal Neoplasms / epidemiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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