| Gender differences in cholesterol-lowering medication prescribing in peripheral artery disease. | |
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MedLine Citation:
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PMID: 22128042 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Among 320 patients with lower extremity peripheral artery disease (PAD) and low-density lipoprotein-cholesterol (LDL-C) levels > 70 mg/dl, we determined whether male sex, higher education, and greater self-efficacy for willingness to request therapy from one's physician were associated with increases in LDL-C-lowering medication and achievement of an LDL-C level < 70 mg/dl at 1-year follow-up. Participants were enrolled in a randomized controlled clinical trial to determine whether a telephone counseling intervention can help PAD patients achieve an LDL-C level < 70 mg/dl, compared to usual care and attention control conditions, respectively. Adjusting for age, race, comorbidities, PAD severity, and other covariates, male sex (odds ratio = 3.33, 95% confidence interval = 1.64 to 6.77, p = 0.001) was associated with a higher likelihood of adding cholesterol-lowering medication during follow-up, but was not associated with achieving an LDL-C < 70 mg/dl (odds ratio = 1.09, 95% confidence interval = 0.55 to 2.18). No associations of education level or self-efficacy with study outcomes were identified. In conclusion, male PAD patients with baseline LDL-C levels ≥ 70 mg/dl were more likely to intensify LDL-C-lowering medication during 1-year follow-up than female PAD patients. Despite greater increases in LDL-C-lowering medication among female PAD patients, there was no difference in the degree of LDL-C lowering during the study between men and women with PAD. Clinical Trial Registration - URL: http://www.clinicaltrials.gov/ct2/show/NCT00217919. |
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Authors:
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Mary M McDermott; Philip Greenland; George Reed; Kathleen M Mazor; Philip A Merriam; Rex Graff; Huimin Tao; Sherry Pagoto; Larry Manheim; Melina R Kibbe; Ira S Ockene |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Vascular medicine (London, England) Volume: 16 ISSN: 1477-0377 ISO Abbreviation: Vasc Med Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610930 Medline TA: Vasc Med Country: England |
Other Details:
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Languages: eng Pagination: 428-35 Citation Subset: IM |
Affiliation:
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1 Northwestern University Feinberg School of Medicine, Chicago, IL, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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