| Gender differences in autoantibodies to oxidative DNA base damage in cigarette smokers. | |
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MedLine Citation:
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PMID: 11401914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxidative DNA damage and antibodies to that damage have been implicated in lung, breast, and colorectal cancer. In this observational validation study, the relationship between anti-5-hydroxymethyl-2'-deoxyuridine (HMdU) autoantibody (aAb) and plasma micronutrients was assessed in 140 heavy smokers by ELISA. Anti-HMdU aAbs were 50% higher in women after adjustment for cigarettes/day (CPD; P = 0.002), although men smoked more and had higher plasma cotinine levels. The women reported taking more vitamin C (P < 0.005) and had higher plasma levels of alpha-carotene and beta-carotene (P < 0.001) and cryptoxanthin (P < 0.01) than men. Neither CPD nor cotinine was associated with aAb titers. Anti-HMdU aAbs were associated inversely with alpha-tocopherol (P = 0.10), retinol (P = 0.06), and age (P = 0.04) in women but not in men. In contrast to the men, women <or=50 years of age had significantly higher aAbs than those >50 years of age (P = 0.05). Given the same duration of exposure, women had higher anti-HMdU aAbs and also reached peak levels at a lower cumulative smoking exposure (30 years) compared with male smokers (40 years). Subjects smoked an average of 28.9 +/- 0.81 CPD and initiated smoking at 17.2 +/- 0.33 (SE) years of age. Therefore, smokers who reported smoking for 30 years were typically <50 years old. Women <or=50 years in the younger age group that smoked 21-30 years had significantly higher levels of aAbs than did men of the same age and smoking history (P = 0.012). Gender difference in aAbs was also evident in 29 persons who gave serial samples before and after quitting smoking (P < 0.028). In women, aAbs remained elevated for 14 months after smoking cessation but decreased significantly by 20.5 months (P < 0.032) by paired t tests. In men, aAbs increased with time since quitting smoking but not significantly. The finding of significantly elevated aAbs to oxidized DNA in females <or=50 compared with male smokers of the same age and exposure suggests a possible interaction with hormones (e.g., estrogens) and may explain a heightened risk of smoking-induced lung cancer in women compared with men. |
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Authors:
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L A Mooney; F P Perera; A M Van Bennekum; W S Blaner; J Karkoszka; L Covey; Y Hsu; T B Cooper; K Frenkel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Validation Studies |
Journal Detail:
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Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Volume: 10 ISSN: 1055-9965 ISO Abbreviation: Cancer Epidemiol. Biomarkers Prev. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-06-12 Completed Date: 2001-07-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9200608 Medline TA: Cancer Epidemiol Biomarkers Prev Country: United States |
Other Details:
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Languages: eng Pagination: 641-8 Citation Subset: IM |
Affiliation:
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Department of Environmental Health Sciences, Joseph L. Mailman School of Public Health, Columbia University, New York, New York 10032, USA. lam14@columbia.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antineoplastic Agents / analysis, immunology* Autoantibodies / analysis* Biological Markers / analysis DNA Damage* Female Humans Male Middle Aged Oxidative Stress Sex Factors Smoking / adverse effects* Thymidine / analogs & derivatives, analysis, immunology* |
| Grant Support | |
ID/Acronym/Agency:
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1-PO1-ESO5294/ES/NIEHS NIH HHS; 5-R-DA04732/DA/NIDA NIH HHS; AG14587/AG/NIA NIH HHS; CA69094/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Autoantibodies; 0/Biological Markers; 50-89-5/Thymidine; 5116-24-5/5-hydroxymethyl-2'-deoxyuridine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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