Document Detail

Gender differences in angiotensin II and aldosterone secretion in patients with pressure overloaded systemic right ventricles are similar to those observed in systemic arterial hypertension.
MedLine Citation:
PMID:  19896738     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: There are very few and inconclusive data concerning the renin-angiotensin-aldosterone system activity in adults with systemic right ventricles, compared to classic heart failure patients. Therefore, we prospectively evaluated angiotensin II and aldosterone levels in a series of patients following Mustard or Senning procedures for complete transposition of the great arteries.
METHODS: Forty-two patients (31 male and 11 female, mean age 20.8±3.7years), 18.2±2.8years following atrial switch procedures, were included in the analysis. All the patients underwent comprehensive echocardiographic examinations. Angiotensin II and aldosterone levels were measured with immunoradiometric assays.
RESULTS: The mean angiotensin II level was 11.9±9.4pg/mL; 15 patients (35.7%) had angiotensin II levels exceeding the upper limit of normal values. There was a negative correlation between angiotensin II levels and treatment with angiotensin enzyme inhibitors (r=-0.33, P=0.03). The mean aldosterone level was 217.7±160.2pg/mL; 26 patients (61.9%) had aldosterone levels exceeding the upper limit of normal values. Female patients had significantly higher aldosterone levels than male patients (321±248 vs 180±95pg/mL, P=0.01). A negative correlation between angiotensin II levels and fractional area change (r=-0.65, P=0.03), and a positive correlation between aldosterone levels and right ventricular end-diastolic area (r=0.66, P=0.03) were observed in female but not in male patients.
CONCLUSIONS: Renin-angiotensin-aldosterone axis activation in patients with systemic right ventricles was similar to reported values in other studies of stable heart failure. The gender differences in aldosterone levels in patients with systemic right ventricles were similar to that associated with left ventricular remodeling in systemic arterial hypertension.
Piotr Szymański; Anna Klisiewicz; Barbara Lubiszewska; Magdalena Lipczyńska; Mirosław Kowalski; Jadwiga Janas; Piotr Hoffman
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Publication Detail:
Type:  Journal Article     Date:  2009-11-07
Journal Detail:
Title:  International journal of cardiology     Volume:  147     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  366-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
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