Document Detail


Gender differences in adrenergic regulation of lipid mobilization during exercise.
MedLine Citation:
PMID:  8884419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gender differences in adrenergic regulation of glycerol levels in subcutaneous, abdominal adipose tissue were investigated during submaximal exercise in non-obese, healthy men and women, using microdialysis. During exercise, glycerol levels in venous plasma and venous serum concentrations of free fatty acids increased more in women and reached about two-fold higher values than in men (p < 0.005 or less). Plasma noradrenaline and insulin did not differ between the sexes, whereas plasma adrenaline was two-fold higher in men than in women during exercise (p < 0.01). The glycerol levels in adipose tissue increased during exercise and decreased in the post-exercise period in either sex. When the non-selective beta adrenoceptor blocking agent propranolol was added to the microdialysis perfusate before exercise was initiated, the subsequent increase in dialysate glycerol was significantly diminished in both sexes (p < 0.05). A similar addition of the alpha adrenoceptor blocking agent phentolamine, however, caused a significant further rise in tissue glycerol in men (p < 0.05), whereas the exercise induced increase in glycerol levels remained unaffected by phentolamine in women. Adipose tissue blood flow did not change during exercise in either men or women. In either sex, dialysate lactate levels increased during exercise. This increase was not altered if alpha- or beta-blocking agents were added to the perfusate. In summary, during short term submaximal work, women have a higher increase in circulating lipid than men. This appears, at least in part, to be due to a sex difference in the adrenergic regulation of lipid mobilization during exercise. In men exercise activates beta- as well as alpha-adrenergic receptors in adipose tissue, whereas only beta receptors are activated in adipose tissue of women. Finally, methodological investigations indicate that microdialysis is a valid method for short-term exercise experiments.
Authors:
L Hellström; E Blaak; E Hagström-Toft
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of sports medicine     Volume:  17     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-01-23     Completed Date:  1997-01-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  439-47     Citation Subset:  IM    
Affiliation:
Department of Medicine, Huddinge Hospital, Karolinska Institute, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / chemistry
Adult
Catecholamines / blood
Exercise / physiology*
Fatty Acids, Nonesterified / analysis
Female
Glycerol / analysis
Humans
Lipid Mobilization / physiology*
Male
Microdialysis
Receptors, Adrenergic / physiology*
Sex Characteristics*
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Fatty Acids, Nonesterified; 0/Receptors, Adrenergic; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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