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Gender differences in adenine-induced chronic kidney disease and cardiovascular complications in rats.
MedLine Citation:
PMID:  25209863     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Gender contributes to differences in incidence and progression of chronic kidney disease (CKD) and associated cardiovascular disease. 0.25% adenine diet for 16 weeks was used to induce kidney damage in male and female Wistar rats (n=12/group). Kidney function (blood urea nitrogen/BUN, plasma creatinine/PCr, proteinuria) and structure (glomerular damage, tubulointerstitial atrophy, fibrosis, inflammation), cardiovascular function (blood pressure, ventricular stiffness, vascular responses, echocardiography) and structure (cardiac fibrosis), plasma testosterone and estrogen concentrations, and protein expression for oxidative stress (heme-oxygenase-1, HO-1), inflammation (tumor necrosis factor-α, TNF-α), fibrosis (transforming growth factor-β, TGF-β), extracellular signal-regulated kinase (ERK1/2), and estrogen receptor-α (ER-α) were compared in males and females. Adenine-fed females had less decline in kidney function than adenine-fed males, although kidney atrophy, inflammation, and fibrosis were similar. Plasma estrogen concentrations increased and plasma testosterone concentrations decreased in adenine-fed males, with smaller changes in females. CKD-associated molecular changes in kidneys were more pronounced in males than females except for expression of ER-α in the kidney which was completely suppressed in adenine-fed males, but unchanged in adenine-fed females. Both genders showed increased blood pressure, ventricular stiffness and cardiac fibrosis with adenine diet. Cardiovascular changes with adenine were similar in males and females, except males developed concentric, and females eccentric cardiac hypertrophy. In hearts from adenine-fed male and female rats, expression of ER-α and activation of the ERK1/2 pathway were increased, in part explaining changes in cardiac hypertrophy. In summary, adenine-induced kidney damage may be increased in males due to the suppression of ER-α.
Authors:
Vishal Diwan; David M Small; Kate Kauter; Glenda C Gobe; Lindsay Brown
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-10
Journal Detail:
Title:  American journal of physiology. Renal physiology     Volume:  -     ISSN:  1522-1466     ISO Abbreviation:  Am. J. Physiol. Renal Physiol.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901990     Medline TA:  Am J Physiol Renal Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013, American Journal of Physiology - Renal Physiology.
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