| Gender difference in the relation blood pressure-left ventricular mass and geometry in newly diagnosed arterial hypertension. | |
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MedLine Citation:
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PMID: 22545829 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Much evidence suggests sexual dimorphism in the relationship linking blood pressure (BP) to both left ventricular mass (LVM) and geometry in hypertension. To better evaluate gender-associated characteristics in the relation BP-LVM among newly diagnosed hypertension (24-h average ambulatory BP monitoring, ABPM, > 125/80 mmHg), we measured indexed LVM and relative wall thickness (RWT) by standardized echographic methods in 209 Caucasian drug-naïve subjects, of whom 162 (100M/62F) were recognized to be hypertensive. Mean office systolic (SBP)/diastolic (DBP), 24-h average and night-time BP values were similar between sexes and significantly related to indexed LVM in both genders. Daytime SBP was significantly related to indexed LVM only in females (r = 0.41; p = 0.0008 in women; r = 0.11; p = NS in males), while LVM was more sensitive to day-to-night SBP change in females. RWT was, on the contrary, significantly related to ABPM values only in males. All these findings were confirmed after adjusting for possible confounders. Percentage of LVM variance explained by 24-h average, daytime or night-time SBP values were higher in females than in males (17% vs 3%; 11% vs 1%; and 17% vs 8%). In conclusion, in early hypertension, LVM was significantly associated with daytime BP and more sensitive to reduced percentage of night BP fall in females. LVM variance explained by ABPM SBP was much higher in females than in males. RWT, expressing concentric LVM remodelling was, conversely, more related to BP increase in males. |
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Authors:
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Franco Cipollini; Enrica Arcangeli; Emanuela Greco; Flavia Franconi; Giuseppe Pettinà; Giuseppe Seghieri |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-1 |
Journal Detail:
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Title: Blood pressure Volume: - ISSN: 1651-1999 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9301454 Medline TA: Blood Press Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Internal Medicine, Spedali Riuniti, Viale Matteotti 9/D , 51100 Pistoia , Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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