| Gender dichotomy in reactivity to the vasoactive oxidant hydrogen peroxide in spontaneously hypertensive rats. | |
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MedLine Citation:
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PMID: 12078058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine: 1) whether ovariectomy increases low-density lipoprotein (LDL) cholesterol; 2) if increased LDL cholesterol correlates with increased blood pressure; and 3) whether arterial muscle reactivity to the vasoactive oxidant hydrogen peroxide (H2O2) is gender-dependent in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). METHODS: SHR and WKY females were ovariectomized at four weeks of age. Blood pressures were monitored weekly. Blood was collected at the time of sacrifice at 16-18 weeks, and caudal arteries were excised. LDL cholesterol was measured. Caudal arterial muscle was contracted with high-calcium egtazic acid (EGTA)/ionomycin (calcium ionophore) and relaxed with zero-calcium EGTA/ionomycin. H2O2-induced contractions were elicited in zero calcium. H2O2 reactivity was compared for SHR and WKY, male and female arterial muscle. RESULTS: Ovariectomy increased LDL cholesterol in both SHR and WKY but blood pressure increased only in SHR. Male SHR and WKY arterial muscle was more reactive to H2O2 compared with female preparations. CONCLUSION: Gender dichotomy in the development of hypertension does not appear to be due directly to the LDL-lowering effects of estrogen but is likely due, at least in part, to lower arterial reactivity to vasoactive oxidants, such as H2O2, with a consequent reduction of oxidant-induced vasoconstriction in female SHR. |
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Authors:
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C Subah Packer; Nancy J Pelaez; Tomalyn C Johnson |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia Volume: 5 ISSN: 1523-7036 ISO Abbreviation: J Gend Specif Med Publication Date: 2002 May-Jun |
Date Detail:
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Created Date: 2002-06-24 Completed Date: 2002-12-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100887298 Medline TA: J Gend Specif Med Country: United States |
Other Details:
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Languages: eng Pagination: 17-23 Citation Subset: IM |
Affiliation:
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Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, IN 46202, USA. spacker1@iupui.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / drug effects Cholesterol, LDL / blood* Disease Models, Animal Female Hydrogen Peroxide* / metabolism Hypertension / blood, complications*, physiopathology Male Muscle, Smooth, Vascular / drug effects* Ovariectomy Oxidants* / metabolism Rats Rats, Inbred SHR Rats, Inbred WKY Sex Factors Tail / blood supply |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL; 0/Oxidants; 7722-84-1/Hydrogen Peroxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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