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Gender-dependent negative correlation of peripheral E2 estradiol levels with ventricular diastolic functions.
MedLine Citation:
PMID:  25413860     Owner:  NLM     Status:  Publisher    
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a primary myocardial disease characterized by varying degrees of myocardial hypertrophy. Impairment of left ventricular (LV) diastolic functions is a typical feature of HCM. Clinical studies showed that estrogen replacement therapy could improve ventricular systolic or diastolic functions.
AIM: To investigate the correlation of the peripheral concentrations of one representative estrogen, E2 estradiol, with various indicators reflecting different aspects of cardiac structures and functions.
METHODS: A total of 84 typical patients with HCM and 77 healthy subjects were enrolled. Venous blood samples were taken to test E2 estradiol contents. Echocardiographic imaging was performed to record various indices of cardiac structures and functions.
RESULTS: Concentrations of peripheral E2 estradiol were decreased in female HCM patients, compared to female normal controls;; after medical treatment, peripheral E2 estradiol levels were elevated, nearly to normal levels. Peripheral E2 estradiol concentrations were negatively correlated with LAV (r2 = 0.5078, p < 0.001), LAVI (r2 = 0.4257, p < 0.001), E/A ratio (r2 = 0.4328, p = 0.006) and E/Ea ratio (r2 = 0.4393, p < 0.001) in female controls and patients.
CONCLUSION: Concentrations of peripheral E2 estradiol were negatively correlated with ventricular diastolic functions and this correlation was gender--dependent. Our study could provide clues to explore the molecular mechanisms of HCM, and clinic evidence for the diagnosis and prognostic management of HCM patients, as well as medical intervening for HCM.
B Tan; L Zhao; F He
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-21
Journal Detail:
Title:  Minerva cardioangiologica     Volume:  -     ISSN:  1827-1618     ISO Abbreviation:  Minerva Cardioangiol     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-21     Completed Date:  -     Revised Date:  2014-11-21    
Medline Journal Info:
Nlm Unique ID:  0400725     Medline TA:  Minerva Cardioangiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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