Document Detail


Gender comparison of efficacy and safety of ranolazine for chronic angina pectoris in four randomized clinical trials.
MedLine Citation:
PMID:  17196454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
More women than men with myocardial infarction have previous stable angina pectoris. Women also have an increased incidence of angina after percutaneous coronary intervention and coronary artery bypass grafting. Data from 1,737 patients with stable angina pectoris in 4 international trials (Monotherapy Assessment of Ranolazine In Stable Angina [MARISA], Combination Assessment of Ranolazine In Stable Angina [CARISA], Ranolazine Versus Atenolol Comparison in Chronic Angina [RAN080], and Efficacy of Ranolazine in Chronic Angina [ERICA]) were used to compare efficacy and safety of ranolazine therapy for angina in women and men. MARISA, CARISA, and RAN080 included exercise testing; CARISA, RAN080, and ERICA assessed angina frequency and nitroglycerin consumption; and ERICA included quality-of-life assessment using the Seattle Angina Questionnaire. MARISA, CARISA, and ERICA used the extended-release formulation of ranolazine; RAN080 used ranolazine immediate release. All 4 studies showed overall efficacy and safety of ranolazine. In subgroup analyses, women showed less improvement than men in exercise testing. However, similar improvements for women and men were noted in angina frequency and nitroglycerin consumption, and in ERICA, in the angina frequency dimension of the Seattle Angina Questionnaire. In conclusion, explanations for the gender treatment differences for exercise parameters but comparable effects on decrease in angina frequency and nitroglycerin use are uncertain, but may include differences in patient demographics, reasons for stopping exercise, and type of exercise protocol used.
Authors:
Nanette K Wenger; Bernard Chaitman; George W Vetrovec
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-11-02
Journal Detail:
Title:  The American journal of cardiology     Volume:  99     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-01     Completed Date:  2007-02-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  11-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Emory University School of Medicine, Grady Memorial Hospital, Atlanta, GA, USA. nwenger@emory.edu
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MeSH Terms
Descriptor/Qualifier:
Acetanilides
Aged
Angina Pectoris / blood,  drug therapy*,  pathology
Enzyme Inhibitors / administration & dosage,  adverse effects,  therapeutic use*
Female
Gender Identity*
Humans
Male
Piperazines / administration & dosage,  adverse effects,  therapeutic use*
Questionnaires
Randomized Controlled Trials as Topic
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Acetanilides; 0/Enzyme Inhibitors; 0/Piperazines; 110445-25-5/ranolazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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