Document Detail


Gender-associated differences in metabolic syndrome-related parameters in Göttingen minipigs.
MedLine Citation:
PMID:  17974133     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gender-associated differences in pathophysiology and treatment of disease are an evolving area in human medicine that should be addressed in animal models. The aim of this study was to characterize gender differences in metabolic parameters of Göttingen minipigs and to determine which gender has the metabolic profile that is most appropriate as a model for human metabolic syndrome. Blood samples were collected from fasted, lean male and female Göttingen minipigs at 8 wk and 8 mo of age. Samples were analyzed for glucose, fructosamine, insulin, C-peptide, glucagon, triglycerides, total cholesterol, high-density lipoprotein cholesterol (HDL-c), free fatty acids, leptin, testosterone, and 17beta-estradiol. Insulin sensitivity and beta cell function were estimated by homeostasis model assessment and degree of obesity by measuring the abdominal circumference. Male minipigs had higher concentrations of both testosterone and estradiol. Female minipigs had a larger abdominal circumference and higher concentrations of C-peptide, insulin, triglyceride, total cholesterol, HDL-c and leptin but a lower concentration of free fatty acids and lower HDL-c:total cholesterol ratio. Compared with male minipigs, female minipigs were more insulin-resistant and had a higher beta-cell function. No gender-associated differences were found in any of the other investigated parameters. In conclusion, female minipigs were more obese and insulin-resistant and had a more atherogenic plasma profile than did their male counterparts and therefore may be better models for metabolic syndrome. Their high concentrations of both testosterone and estradiol may protect male minipigs from obesity and metabolic disturbances.
Authors:
Berit Oestergaard Christoffersen; Nanna Grand; Valeria Golozoubova; Ove Svendsen; Kirsten Raun
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Comparative medicine     Volume:  57     ISSN:  1532-0820     ISO Abbreviation:  Comp. Med.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-11-02     Completed Date:  2008-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100900466     Medline TA:  Comp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  493-504     Citation Subset:  IM    
Affiliation:
Department of Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark. BQC@novonordisk.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Birth Weight
Body Fat Distribution
Disease Models, Animal*
Estradiol / blood
Female
Glucose / metabolism
Humans
Lipid Metabolism
Male
Metabolic Syndrome X / blood*,  etiology
Sex Factors
Swine
Swine, Miniature*
Testosterone / blood
Chemical
Reg. No./Substance:
50-28-2/Estradiol; 50-99-7/Glucose; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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