Document Detail

Gender Differences in the Phosphorus Content of the Sino-atrial Nodes and Other Cardiac Regions of Monkeys.
MedLine Citation:
PMID:  21120705     Owner:  NLM     Status:  In-Data-Review    
To examine whether there were gender differences in the sino-atrial node (SAN), the authors investigated the gender difference in the SAN using monkey hearts by direct chemical analysis from a viewpoint of element contents. The used rhesus and Japanese monkeys consisted of 30 males (average age = 6.5 ± 7.5 years) and 30 females (average age = 12.2 ± 10.3 years), ranging in age from newborn to 30 years. The SAN tissues were removed from the anatomical position of monkey hearts and were confirmed by means of histological observation. After ashing with nitric acid and with perchloric acid, element contents of the SANs, such as Ca, P, S, Mg, Zn, Fe, and Na, were determined by inductively coupled plasma-atomic emission spectrometry. In addition, gender differences in the right atrial walls, left ventricular walls, mitral valves, and left coronary arteries of monkeys were also investigated as controls. It was found that the P content was significantly higher in females than in males in the SANs of monkeys, but the other six element contents, Ca, S, Mg, Zn, Fe, and Na, were not significantly different between males and females in the SANs of monkeys. Regarding the P content, a similar finding was also obtained in both the right atrial walls and the left ventricular walls of monkeys, but it was not obtained in the mitral valves and the left coronary arteries of monkeys. The P content of tissue is mostly determined by the nucleic acid (DNA and RNA) content and the phospholipid content of tissue. Nucleic acids in the cell nucleus and the cytosol, and phospholipids in the cell membrane are all indicators of metabolically active cells. It is reasonable to presume that the P content in the SAN indicates the active cell density, namely, the number of active cells per volume. Therefore, there is a possibility that the active cell density of the SAN is significantly higher in females than in males.
Yoshiyuki Tohno; Setsuko Tohno; Hiroyasu Satoh; Motoharu Hayashi; Takao Oishi; Takeshi Minami; Pasuk Mahakkanukrauh
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Publication Detail:
Type:  Journal Article     Date:  2010-12-01
Journal Detail:
Title:  Biological trace element research     Volume:  143     ISSN:  1559-0720     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  871-81     Citation Subset:  IM    
Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand,
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