Document Detail

Gender differences in the pathophysiology, clinical presentation, and outcomes of ischemic heart failure.
MedLine Citation:
PMID:  22864856     Owner:  NLM     Status:  MEDLINE    
Despite advances in the treatment of acute myocardial infarction (MI), heart failure (HF) remains a frequent acute and long-term outcome of ischemic heart disease (IHD). In response to acute coronary ischemia, women are relatively protected from apoptosis, and experience less adverse cardiac remodeling than men, frequently resulting in preservation of left ventricular size and ejection fraction. Despite these advantages, women are at increased risk for HF- complicating acute MI when compared with men. However, women with HF retain a survival advantage over men with HF, including a decreased risk of sudden death. Sex-specific treatment of HF has been hindered by historical under-representation of women in clinical trials, though recent work has suggested that women may have a differential response to some therapies such as cardiac resynchronization. This review highlights the sex differences in the pathophysiology, clinical presentation and outcomes of ischemic heart failure and discusses key areas worthy of further investigation.
Shannon M Dunlay; Véronique L Roger
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current heart failure reports     Volume:  9     ISSN:  1546-9549     ISO Abbreviation:  Curr Heart Fail Rep     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-07     Completed Date:  2013-04-30     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  101196487     Medline TA:  Curr Heart Fail Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267-76     Citation Subset:  IM    
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MeSH Terms
Heart Failure / epidemiology,  etiology,  physiopathology*,  therapy
Myocardial Infarction / complications
Risk Factors
Sex Characteristics*
Treatment Outcome
Ventricular Remodeling / physiology
Grant Support

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