| Gender differences in the association of C-reactive protein with coronary artery calcium in type-2 diabetes. | |
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MedLine Citation:
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PMID: 20874770 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Plasma C-reactive protein (CRP) is associated with cardiovascular disease (CVD), but effects may vary by gender and degree of CVD risk. Whether CRP has value as a CVD risk marker in type-2 diabetes (T2DM) is unclear. We examined whether CRP has gender differences in association with coronary artery calcium (CAC) in diabetic and nondiabetic samples without clinical CVD. METHODS: We performed cross-sectional analyses of gender influence on CRP association with CAC in the Penn Diabetes Heart Study (N = 1299 with T2DM), the Study of Inherited Risk of Coronary Atherosclerosis (N = 860 nondiabetic subjects) and a combined sample. RESULTS: Female gender was associated with higher plasma CRP in diabetic and nondiabetic samples after adjustment for covariates. There was a strong interaction by gender in the association of CRP with CAC (interaction P < 0·001). In diabetic women, CRP was associated with higher CAC even after further adjustment for age, race, medications, metabolic syndrome, Framingham risk score and body mass index [Tobit ratio 1·60, 95% CI (1·03-2·47)]. Although this relationship was attenuated in nondiabetic women, the combined sample maintained this association in fully adjusted models [1·44, 95% CI (1·13-1·83)]. There was no association of CRP with CAC in either diabetic or nondiabetic men. CONCLUSIONS: CRP may be a useful marker of cardiovascular risk in women, particularly in diabetic women who otherwise have no known CVD. Prospective studies are needed to better assess the gender differences in CRP utility and the use of CRP in T2DM. |
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Authors:
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Atif N Qasim; Venkata Budharaju; Nehal N Mehta; Caitlin St Clair; Samira Farouk; Seth Braunstein; Mark Schutta; Nayyar Iqbal; Daniel J Rader; Muredach P Reilly |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Clinical endocrinology Volume: 74 ISSN: 1365-2265 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-16 Completed Date: 2011-03-31 Revised Date: 2012-01-04 |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 44-50 Citation Subset: IM |
Copyright Information:
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© 2010 Blackwell Publishing Ltd. |
Affiliation:
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The Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged C-Reactive Protein / metabolism* Coronary Artery Disease / metabolism* Cross-Sectional Studies Diabetes Mellitus, Type 2 / metabolism* Female Humans Male Middle Aged Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
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K23 HL097151-02/HL/NHLBI NIH HHS; M01 RR000040-440895/RR/NCRR NIH HHS; P20-DK 019525/DK/NIDDK NIH HHS; P50 HL-083799/HL/NHLBI NIH HHS; R01 HL-073278/HL/NHLBI NIH HHS; UL1 RR024134-05/RR/NCRR NIH HHS; UL1RR024134/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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