Document Detail

Gender difference in baroreflex sensitivity to predict cardiac and cerebrovascular events in type 2 diabetic patients.
MedLine Citation:
PMID:  21478631     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cardiovascular autonomic neuropathy is a major complication in patients with diabetes mellitus (DM), and baroreflex sensitivity (BRS) reportedly can predict cardiovascular prognosis in type 2 DM patients. The hypothesis that cardiovascular events are associated with gender differences in BRS was tested in the present study.
METHODS AND RESULTS: From 1998, we have evaluated BRS by phenylephrine methods in 185 consecutive type 2 DM patients. The long-term prognostic value of BRS was compared between 91 female (5812 years) and 94 male patients (5811 years). There was no significant difference in age or severity and duration of DM between the 2 groups. When compared to male, the BRS value in female patients was significantly lower (9.266.0 vs. 5.975.0 ms/mmHg, P < 0.0001). During a mean of 62.7 months of follow-up, 16 female patients developed cardiovascular events (17.6%) including stroke, acute myocardial infarction, angina pectoris requiring percutaneous coronary intervention or coronary artery bypass grafting and congestive heart failure requiring admission, while only 4 male patients developed events (4.3%, P < 0.005). In females, the Kaplan-Meier curves revealed that those with depressed BRS (< 6 ms/mmHg) had a higher incidence of cardiovascular events than those with preserved BRS (P < 0.05), but this relationship was not observed in male patients.
CONCLUSIONS: Although the reason why females had a more depressed BRS remains unclear, our findings demonstrated that a depressed BRS value can accurately predict cardiovascular events, especially in female patients with type 2 DM.
Kunio Yufu; Naohiko Takahashi; Norihiro Okada; Osamu Wakisaka; Tetsuji Shinohara; Mikiko Nakagawa; Masahide Hara; Hironobu Yoshimatsu; Tetsunori Saikawa
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-04-09
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  75     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-26     Completed Date:  2011-09-16     Revised Date:  2012-01-09    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1418-23     Citation Subset:  IM    
Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, Yufu, Japan.
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MeSH Terms
Analysis of Variance
Autonomic Nervous System / physiopathology*
Cerebrovascular Disorders / etiology*,  mortality,  physiopathology
Chi-Square Distribution
Diabetes Mellitus, Type 2 / complications*,  mortality,  physiopathology
Diabetic Neuropathies / etiology*,  mortality,  physiopathology
Heart Diseases / etiology*,  mortality,  physiopathology
Kaplan-Meier Estimate
Middle Aged
Proportional Hazards Models
Risk Assessment
Risk Factors
Sex Factors
Time Factors
Comment In:
Circ J. 2011;75(6):1320-1   [PMID:  21478629 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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