| Gemfibrozil improves abnormalities of lipid metabolism in patients on continuous ambulatory peritoneal dialysis: the role of postheparin lipases in the metabolism of high-density lipoprotein subfractions. | |
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MedLine Citation:
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PMID: 2507877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-five CAPD patients were given gemfibrozil in increasing doses for a total of 14 weeks. Parameters of lipid metabolism including serum total cholesterol, LDL cholesterol, HDL cholesterol, HDL2 cholesterol, HDL3 cholesterol triglyceride, apolipoprotein A-1, apolipoprotein B, postheparin lipoprotein lipase, and hepatic lipase activities were measured before the commencement, at every increment in the dose of gemfibrozil and 4 weeks after discontinuation of therapy. Gemfibrozil normalized the deranged parameters of lipid metabolism. Thus, with treatment, serum triglyceride, and total cholesterol, LDL cholesterol and apo B decreased, whereas serum HDL cholesterol, HDL2, and HDL3 (predominantly the latter subfraction), hepatic lipoprotein lipase activities increased. Apo A-1 did not change significantly. Even in normotriglyceridemic patients serum HDL cholesterol increased. The side effects consisted of muscle aches and a significant rise in serum CPK. Gemfibrozil produced a significant decrease in gamma-GT activities. A possible mechanism for the interconversion between HDL2 and HDL3 that resulted in a preferential increase in the latter was discussed. It was concluded that gemfibrozil, in a dose not exceeding 300 mg twice a day favorably improved the risk factor for ischemic heart disease in CAPD patients. |
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Authors:
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M K Chan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 38 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 1989 Oct |
Date Detail:
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Created Date: 1989-11-14 Completed Date: 1989-11-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 939-45 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Hong Kong, Queen Mary Hospital. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Apolipoprotein A-I Apolipoproteins A / metabolism Apolipoproteins B / metabolism Cholesterol / metabolism Cholesterol, HDL / metabolism Cholesterol, LDL / metabolism Drug Evaluation Female Gemfibrozil / administration & dosage, therapeutic use* Humans Hyperlipidemias / prevention & control* Lipid Metabolism* Lipoprotein Lipase / metabolism* Lipoproteins, HDL / metabolism* Liver / enzymology, metabolism Male Middle Aged Peritoneal Dialysis, Continuous Ambulatory* / adverse effects Time Factors Triglycerides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein A-I; 0/Apolipoproteins A; 0/Apolipoproteins B; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipoproteins, HDL; 0/Triglycerides; 25812-30-0/Gemfibrozil; 57-88-5/Cholesterol; EC 3.1.1.34/Lipoprotein Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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