Document Detail

Gemcitabine-induced acute coronary syndrome: a case report.
MedLine Citation:
PMID:  19060498     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To report a case of metastatic leiomyosarcoma, in which a patient developed chest pain accompanied by acute left bundle-branch block (LBBB) after gemcitabine infusion.
CLINICAL PRESENTATION AND INTERVENTION: A 59-year-old woman admitted with bilateral pulmonary nodules had classic risk factors for coronary heart disease and coronary stenosis as demonstrated by previous coronary angiography. She was treated with gemcitabine infusion, and 30 min later she experienced severe chest pain accompanied by acute LBBB confirmed by ECG. We suspected gemcitabine-induced coronary vasospasm exacerbated by the preexisting coronary artery disease as the cause of the acute coronary syndrome. The patient was subsequently treated with antianginal therapy and percutaneous coronary intervention. Her chest pain resolved and LBBB disappeared. She was discharged 2 days later without any further cardiac events. No additional cancer therapy was given and she died 5 months later, due to disease progression.
CONCLUSION: This case showed that chemotherapeutic agents must be administered with intensive cardiac monitoring especially in patients with cardiac disease and well-known risk factors to prevent the development of cardiac complications, despite an agent not being known to be 'cardiotoxic'.
Banu Ozturk; Gulten Tacoy; Ugur Coskun; Emel Yaman; Giray Sahin; Suleyman Buyukberber; Ramazan Yildiz; Ali O Kaya; Salih Topal; Murat Ozdemir; Mustafa Benekli
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-12-04
Journal Detail:
Title:  Medical principles and practice : international journal of the Kuwait University, Health Science Centre     Volume:  18     ISSN:  1423-0151     ISO Abbreviation:  Med Princ Pract     Publication Date:  2009  
Date Detail:
Created Date:  2008-12-08     Completed Date:  2009-03-30     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  8901334     Medline TA:  Med Princ Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  76-80     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Department of Medical Oncology, Gazi University Medical School, Ankara, Turkey.
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MeSH Terms
Antimetabolites, Antineoplastic / adverse effects*
Aspirin / therapeutic use
Bundle-Branch Block / chemically induced*,  diagnosis,  drug therapy
Coronary Artery Disease / complications*
Coronary Vasospasm / chemically induced
Deoxycytidine / adverse effects,  analogs & derivatives*
Fatal Outcome
Lung Neoplasms / secondary
Middle Aged
Platelet Aggregation Inhibitors / therapeutic use
Risk Factors
Ticlopidine / analogs & derivatives,  therapeutic use
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin; 55142-85-3/Ticlopidine; 951-77-9/Deoxycytidine; A74586SNO7/clopidogrel; B76N6SBZ8R/gemcitabine

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