Document Detail

Gemcitabine-associated posterior reversible encephalopathy syndrome: MR imaging and MR spectroscopy findings.
MedLine Citation:
PMID:  11295355     Owner:  NLM     Status:  MEDLINE    
A 55 year old female receiving gemcitabine for stage IV non-small cell carcinoma of the lung developed the clinical-radiologic syndrome of posterior reversible encephalopathy syndrome (PRES). She had clinical manifestations of headaches, increasing somnolence and tonic-clonic seizures. The fluid-attentuated inversion recovery (FLAIR) MR imaging sequence conspicuously showed bihemispheric, symmetrical cortical and subcortical white matter hyperintensities that preponderantly involved the parietal and occipital lobes. Diffusion-weighted imaging (DWI) sequence reflected the preponderant existence of vasogenic edema in the involved areas. MR spectroscopy showed no significant N-acetyl aspartate (NAA) depletion or lactate elevation prospectively, indicating the absence of significant neuronal loss and reversibility of the brain parenchymal changes. The clinical and radiologic manifestations essentially resolved completely with discontinuation of the drug.
M T Russell; A S Nassif; E D Cacayorin; E Awwad; W Perman; F Dunphy
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Magnetic resonance imaging     Volume:  19     ISSN:  0730-725X     ISO Abbreviation:  Magn Reson Imaging     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-04-11     Completed Date:  2001-06-14     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  8214883     Medline TA:  Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  129-32     Citation Subset:  IM    
Saint Louis School of Medicine, St. Louis University Hospital, St. Louis, MO 63110, USA.
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MeSH Terms
Antimetabolites, Antineoplastic / adverse effects*,  therapeutic use*
Brain / pathology
Brain Injuries / chemically induced*,  pathology*
Carcinoma, Non-Small-Cell Lung / drug therapy*
Deoxycytidine / adverse effects*,  analogs & derivatives,  therapeutic use*
Lung Neoplasms / drug therapy*
Magnetic Resonance Imaging*
Magnetic Resonance Spectroscopy*
Middle Aged
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 951-77-9/Deoxycytidine; B76N6SBZ8R/gemcitabine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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