| Gemcitabine-associated large vessel vasculitis presenting as fever of unknown origin. | |
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MedLine Citation:
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PMID: 20407388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gemcitabine is a nucleoside analogue used for treatment of multiple cancers. Recent reports describe small to medium vessel vasculitis as a rare complication of therapy. We report a case of significant large vessel vasculitis presenting as fever of unknown origin in a patient treated adjuvantly with docetaxel and gemcitabine for uterine leiomyosarcoma.The patient presented after her first and second exposure to chemotherapy with fever of unknown origin and worsening subsequent chest and neck discomfort. Extensive workup revealed radiographic and laboratory evidence of aortic vasculitis. We initiated treatment with high-dose corticosteroids, and the patient's condition resolved without complication over the next several weeks.To our knowledge, this represents the first case of gemcitabine-induced large vessel vasculitis which presented in our case as fever of unknown origin. Awareness of this potential complication is essential as discontinuing the inciting drug and initiating corticosteroid treatment can be life-saving. |
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Authors:
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Laura B Ramsay; Michael P Stany; Jess D Edison; Sarah A Bernstein; Kevin E Schlegal; Chad A Hamilton |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases Volume: 16 ISSN: 1536-7355 ISO Abbreviation: J Clin Rheumatol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9518034 Medline TA: J Clin Rheumatol Country: United States |
Other Details:
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Languages: eng Pagination: 181-2 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Walter Reed Army Medical Center, Washington, DC 20307, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antimetabolites, Antineoplastic
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adverse effects* Aortitis / chemically induced*, complications, radionuclide imaging Deoxycytidine / adverse effects, analogs & derivatives* Female Fever of Unknown Origin / etiology Fluorodeoxyglucose F18 / diagnostic use Humans Middle Aged Positron-Emission Tomography |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites, Antineoplastic; 103882-84-4/gemcitabine; 63503-12-8/Fluorodeoxyglucose F18; 951-77-9/Deoxycytidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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