Document Detail

Gelsolin in human colon adenocarcinoma cells with different metastatic potential.
MedLine Citation:
PMID:  19956804     Owner:  NLM     Status:  MEDLINE    
Gelsolin, one of a major actin-binding proteins, is involved in the regulation of actin cytoskeleton organization by its severing and capping activity towards actin filaments. Human colon adenocarcinoma cell line LS180 and its selected variants of different metastatic potential were used to check for a correlation between gelsolin level, its subcellular localization and the invasive capacity of cells. Based on immunoblotting experiments, a decreased level of gelsolin was detected in the most invasive 5W subline when compared to the parental cell line LS180. The intracellular distribution of actin filaments and gelsolin in colon adenocarcinoma cells was examined by confocal microscopy. In the 5W subline, unlike in the other examined cells, gelsolin was colocalized with filamentous actin at the cell periphery. In summary, in human colon adenocarcinoma cells, gelsolin level and its subcellular distribution seem to correlate with their metastatic potential.
Monika Litwin; Antonina J Mazur; Dorota Nowak; Hans G Mannherz; Maria Malicka-B?aszkiewicz
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Publication Detail:
Type:  Journal Article     Date:  2009-12-04
Journal Detail:
Title:  Acta biochimica Polonica     Volume:  56     ISSN:  1734-154X     ISO Abbreviation:  Acta Biochim. Pol.     Publication Date:  2009  
Date Detail:
Created Date:  2010-01-12     Completed Date:  2010-02-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  14520300R     Medline TA:  Acta Biochim Pol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  739-43     Citation Subset:  IM    
Depratment of Cell Pathology, Faculty of Biotechnology, University of Wroc?aw, Wroc?aw, Poland.
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MeSH Terms
Actins / metabolism
Adenocarcinoma / metabolism*
Cell Line, Tumor
Colonic Neoplasms / metabolism*,  pathology
Gelsolin / metabolism*
Microfilaments / metabolism
Microscopy, Confocal
Neoplasm Invasiveness / pathology
Neoplasm Metastasis / physiopathology
Reg. No./Substance:
0/Actins; 0/Gelsolin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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