Document Detail

Gelatinase-a/mmp-2 serum levels and neoplastic progression in breast-cancer patients.
MedLine Citation:
PMID:  21566957     Owner:  NLM     Status:  In-Data-Review    
The metastatic potential of cancer cells has been associated to their ability to elaborate and secrete basement membrane degradative enzymes. In this process a major role appears to be played by a protease known as gelatinase A (72 kDa type IV collagenase, MMP-2). In an effort to assess the significance of these findings to breast cancer progression, we have evaluated the gelatinase A/MMP-2 serum levels in a cohort of 80 breast cancer patients, 27 subjects affected by benign breast disease and 27 healthy controls. Although differences between the three groups were observed, with the highest values monitored in benign breast disease, they were not statistically significant. On the contrary, within the breast cancer cohort, the patients presenting clinical evidence of distant metastases (M+, n=40) had statistically elevated enzyme serum levels (p<0.03) compared to those without nodal involvement and distant metastases (N-M-, n=20). The statistical significance was still evident when considering the overall M- cohort (including N+ and N- patients, n=40) compared to the M+. Although indicating that, in general, gelatinase A/MMP-2 is not a useful serum marker for breast cancer screening and diagnosis, the findings point toward its involvement in the breast cancer metastatic process and suggest a possible value in monitoring the outcome of the disease.
A Leone; M Correale; C Dragone; A Paradiso; M Delena; W Stetlerstevenson; L Liotta; L Masiero; S Garbisa
Related Documents :
24563327 - Up-regulation and worse prognostic marker of cytoplasmic tarbp2 expression in obstinate...
2694157 - Carotenoids as chemopreventive agents.
21896177 - Adenoid cystic carcinoma intermingled with ductal carcinoma of the breast: a case repor...
22819377 - Intra-prostatic injection of botulinum toxin type a in treatment of dogs with spontaneo...
17626707 - Lessons learnt from a population-based pilot programme for colorectal cancer screening ...
6945007 - Nuclear dna content and the number of barr bodies in premalignant and malignant lesions...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of oncology     Volume:  4     ISSN:  1019-6439     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  2011-05-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  551-4     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Allele loss on chromosome-3 in squamous-cell carcinoma of the head and neck correlates with poor cli...
Next Document:  Interleukin-1 receptor antagonist inhibits growth modulation of human tumor-cell lines by interleuki...