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Gelatin-thrombin matrix-mediated hemostasis : Application in tonsillectomy.
MedLine Citation:
PMID:  23463411     Owner:  NLM     Status:  Publisher    
BACKGROUND: To assess the feasibility of omitting thermal coagulation following cold knife tonsillectomy, we compared the use of a local thrombin hemostat (FloSeal®, FS) to bipolar electrocautery (EK). PATIENTS AND METHODS: A total of 181 patients with chronic tonsillitis or tonsillar hypertrophy were stratified in terms of patient characteristics and randomized before undergoing tonsillectomy. The follow-up period continued until postoperative day 20. RESULTS: FS-treated patients reported lower postoperative pain intensity scores (p = 0.011) and significantly reduced pain duration (p < 0.001). Whilst wound healing appeared to be improved in FS patients, the rates of postoperative hemorrhage remained unchanged. Use of an FS enabled inexperienced surgeons (< 100 procedures) to reduce their operating time by 8 min (p = 0.05), although no effect was observed for experienced surgeons. CONCLUSION: Hemostasis is effectively mediated by an FS and its application reduces postoperative pain intensity and duration. Although we observed accelerated wound healing and reduced operating times owing to a more calculable rate of hemostasis, this did not influence the rates of postoperative hemorrhage.
C Mozet; C Prettin; M Dietze; A Dietz
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-3-7
Journal Detail:
Title:  HNO     Volume:  -     ISSN:  1433-0458     ISO Abbreviation:  HNO     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985099R     Medline TA:  HNO     Country:  -    
Other Details:
Languages:  GER     Pagination:  -     Citation Subset:  -    
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde/Plastische Operationen, Universität Leipzig, Liebigstrasse 10-14, 04103, Leipzig, Deutschland,
Vernacular Title:
Gelatine-Thrombin-Matrix zur Blutstillung : Einsatz bei der Tonsillektomie.
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