| Gelatin Microspheres: Correlation between Embolic Effect/Degradability and Cross-linkage/Particle Size. | |
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MedLine Citation:
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PMID: 23238849 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the embolic effect and degradability of gelatin microspheres (GMS) using various degrees of cross-linkage and particle sizes in rabbit renal artery embolization. METHODS: Four types of GMS were used, as follows: 2 types of cross-linkage and 2 types of particle size. Twenty-four rabbits (6 in each group) were used for the renal artery embolization. Renal angiography was performed before and after embolization of right renal artery. Follow-up renal angiography was performed 2 days (n = 2), 5 days (n = 2), and 15 days (n = 2) after embolization in each group, and then kidneys were removed for histopathological evaluation. Vascular areas of the angiography were measured by Image J software, and the reperfusion rate was calculated. In renal specimens, residual GMS were checked and the degree of degradation was classified according to a 4-point scale. RESULTS: The mean amounts of large- and small-particle-size GMS injected were 15.0 and 34.3 mg, respectively. Tissue necrosis was confirmed in each group; however, no difference was observed among groups. Renal reperfusion was observed more with small GMS than with large GMS. Renal reperfusion was also observed more with low cross-linked GMS than with high cross-linked GMS. In histopathological specimens, large GMS were confirmed in lobar artery, and small GMS were confirmed in lobular artery. Low cross-linked GMS completely degraded 15 days after embolization. In contrast, high cross-linked GMS were persistent 15 days after embolization. CONCLUSION: Degree of cross-linkage and particle size affected degradability and reperfusion. |
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Authors:
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Shinichi Ohta; Norihisa Nitta; Shobu Watanabe; Yuki Tomozawa; Akinaga Sonoda; Hideji Otani; Keiko Tsuchiya; Ayumi Nitta-Seko; Atsuko Yamamoto; Masashi Takahashi; Kiyoshi Murata |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-13 |
Journal Detail:
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Title: Cardiovascular and interventional radiology Volume: - ISSN: 1432-086X ISO Abbreviation: Cardiovasc Intervent Radiol Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8003538 Medline TA: Cardiovasc Intervent Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Radiology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu City, Shiga, 520-2192, Japan, junryuhei@yahoo.co.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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