Document Detail

Gelastic epilepsy and dysprosodia in a case of late-onset right frontal seizures.
MedLine Citation:
PMID:  19733125     Owner:  NLM     Status:  MEDLINE    
Gelastic epilepsy (GE) is an uncommon type of seizure disorder characterized by stereotyped, unprovoked, inappropriate ictal laughter. GE is most frequently associated with hypothalamic hamartoma, with onset almost invariably occurring during childhood. GE also occurs occasionally with temporal and frontal cortical seizure foci. We describe an unusual case of senescent-onset GE with a right frontal seizure focus. In addition to laughter, dysprosodia was a clinical feature. Clinical and electroencephalographic evidence of seizure activity ceased on levetiracetam, and the patient showed concurrent improvement in cognitive function. We review the evidence for the cerebral representation of laughter and prosody, and discuss issues bearing on the differential diagnosis and management of GE.
Steven P Cercy; Joshua E Kuluva
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-09-03
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  16     ISSN:  1525-5069     ISO Abbreviation:  Epilepsy Behav     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-06     Completed Date:  2009-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  360-5     Citation Subset:  IM    
Mental Health Service, Veterans Affairs New York Harbor Healthcare System, New York, NY, USA.
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MeSH Terms
Aged, 80 and over
Anticonvulsants / therapeutic use
Epilepsies, Partial / complications*,  drug therapy
Frontal Lobe / physiopathology*
Magnetic Resonance Imaging / methods
Neuropsychological Tests
Seizures / complications*,  pathology*
Treatment Outcome
Reg. No./Substance:

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