| Gel point and fractal microstructure of incipient blood clots are significant new markers of hemostasis for healthy and anticoagulated blood. | |
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MedLine Citation:
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PMID: 20566899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Here we report the first application of a fractal analysis of the viscoelastic properties of incipient blood clots. We sought to ascertain whether the incipient clot's fractal dimension, D(f,) could be used as a functional biomarker of hemostasis. The incipient clot is formed at the gel point (GP) of coagulating blood, the GP demarcating a functional change from viscoelastic liquid to a viscoelastic solid. Incipient clots formed in whole healthy blood show a clearly defined value of D(f) within a narrow range that represents an index of clotting in health, where D(f) = 1.74 (± 0.07). A significant relationship is found between the incipient clot formation time, T(GP), and the activated partial thromboplastin time, whereas the association of D(f) with the microstructural characteristics of the incipient clot is supported by its significant correlation with fibrinogen. Our study reveals that unfractionated heparin not only prolongs the onset of clot formation but has a significant effect on its fractal microstructure. A progressive increase in unfractionated heparin concentration results in a linear decrease in D(f) and a corresponding prolongation in T(GP). The results represent a new, quantitative measure of clot quality derived from measurements on whole blood samples. |
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Authors:
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Phillip A Evans; Karl Hawkins; Roger H K Morris; Naresh Thirumalai; Roger Munro; Lisa Wakeman; Matthew J Lawrence; P Rhodri Williams |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-21 |
Journal Detail:
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Title: Blood Volume: 116 ISSN: 1528-0020 ISO Abbreviation: Blood Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-29 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
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Languages: eng Pagination: 3341-6 Citation Subset: AIM; IM |
Affiliation:
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School of Medicine, Swansea University, Swansea, United Kingdom. P.A.Evans@swansea.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anticoagulants / pharmacology Blood Coagulation* / drug effects Blood Coagulation Disorders / diagnosis* Blood Viscosity / drug effects Female Fibrinogen / metabolism Hemorheology / drug effects Hemostasis / drug effects Heparin / pharmacology Humans Male Middle Aged Thrombelastography* / methods Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 9001-32-5/Fibrinogen; 9005-49-6/Heparin |
| Comments/Corrections | |
Comment In:
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Blood. 2010 Oct 28;116(17):3123-4
[PMID:
21030568
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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