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Gel from unripe Musa sapientum peel to repair surgical wounds in rats.
MedLine Citation:
PMID:  21952661     Owner:  NLM     Status:  Publisher    
PURPOSE: To determine the optimum concentration of a gel obtained from unripe banana (Musa sapientum) peel for wound treatment in rats. METHODS: A randomized triple blind study was conducted with 40 Wistar rats, which were divided into 4 groups: CG, control group; G2%, 2% gel concentration group; G4%, 4% gel concentration group; and G10%, 10 % gel concentration group. The banana peel gel was applied daily, for 7 days, to a 4-cm² wound created on the back of each animal of all groups. After this period, the wounds were biopsied. Statistical analysis was carried out using the Kruskal-Wallis test complemented by the Student-Newman-Keuls test. RESULTS: Macroscopic examination revealed that partial epithelialization occurred in all groups. Wound contraction was also observed in all groups and ranged from 1.38 to 1.57 mm in the study groups, and from 1.03 to 1.10 mm in the control group, with significant differences (p < 0.05) between the groups: CG and G10%, G2% and G4%, G2% and G10%. The interquartile deviation was smaller between the groups CG and G4%. CONCLUSION: The 4% gel obtained from unripe banana peel (G4%) resulted in better epithelialization of wounds healed by secondary intention compared with other gel concentrations.
Dênia Amélia Novato Castelli Von Atzingen; Alfredo Gragnani; Daniela Francescato Veiga; Luis Eduardo Felipe Abla; Adriana Rodrigues Dos Anjos Mendonça; Clayton Aparecido de Paula; Yara Juliano; José Carlos Correa; Marcio Raimundo de Faria; Lydia Masako Ferreira
Publication Detail:
Type:  -    
Journal Detail:
Title:  Acta cirurgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia     Volume:  26     ISSN:  1678-2674     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9103983     Medline TA:  Acta Cir Bras     Country:  -    
Other Details:
Languages:  ENG     Pagination:  379-382     Citation Subset:  -    
UNIFESP, Sao Paulo, Brazil.
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